|Related Categories||1.11.x.x Peroxide as receptor, 1.x.x.x Oxidoreductases, Application Index, Biochemicals and Reagents, Cell Biology,|
|aqueous buffers such as 50 mM sodium acetate: soluble (Freezing of the enzyme in solution may result in a substantial loss of activity.)|
|shipped in||dry ice|
|Gene Information||human ... MPO(4353)|
Source material tested and found negative for antibody to HIV and for HBSAG.
Catalyzes oxidations by hydrogen peroxide, including cytotoxic actions on bacteria, fungi, and tumor cells. Also catalyzes cross-linking of immune complexes and inactivates chemotactic factors.
Lysosomal heme-containing protein.
One unit will produce an increase in absorbance (A470) of 1.0 per min at pH 7.0 and 25 °C, calculated from the initial rate of reaction using guaiacol as substrate. Total reaction volume: 3.035 mL.
Lyophilized from 50 mM sodium acetate buffer, pH 6.0, 0.1 M sodium chloride
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Purified for use with peroxidase and peroxidase-coupled reactions.
Hanker-Yates substrate kit
DAB substrate kit
From our library of Related Content, Sigma-Aldrich presents Enzyme Explorer: the most comprehensive source of enzymes, substrates, activators, & inhibitors.
Keywords: Cell culture, Cell disruption, Cell signaling, Diagnostic, Digestions, Drug discovery, Functional genomics, Gene expression, Genomics, Metabolic Pathways, Molecular biology, Neuroscience, Proteomics
The myeloperoxidase product hypochlorous acid generates irreversible high-density lipoprotein receptor inhibitors. Binder V, Ljubojevic S, Haybaeck J, et al. Arterioscler. Thromb. Vasc. Biol. 33(5), 1020-7, (2013)
Nrf2 is not required for epithelial prohibitin-dependent attenuation of experimental colitis. Kathiria AS, Butcher MA, Hansen JM, et al. Am. J. Physiol. Gastrointest. Liver Physiol. 304(10), G885-96, (2013)
A novel benzo[d]imidazole derivate prevents the development of dextran sulfate sodium-induced murine experimental colitis via inhibition of NLRP3 inflammasome. Liu W, Guo W, Wu J, et al. Biochem. Pharmacol. 85(10), 1504-12, (2013)
Ocular inflammation and corneal permeability alteration by benzalkonium chloride in rats: a protective effect of a myosin light chain kinase inhibitor. Droy-Lefaix MT, Bueno L, Caron P, et al. Invest. Ophthalmol. Vis. Sci. 54(4), 2705-10, (2013)
Berberine attenuates bleomycin induced pulmonary toxicity and fibrosis via suppressing NF-κB dependant TGF-β activation: a biphasic experimental study. Chitra P, Saiprasad G, Manikandan R, et al. Toxicol. Lett. 219(2), 178-93, (2013)
Serum phospholipid fatty acids, genetic variation in myeloperoxidase, and prostate cancer risk in heavy smokers: a gene-nutrient interaction in the carotene and retinol efficacy trial. Cheng TY, King IB, Barnett MJ, et al. Am. J. Epidemiol. 177(10), 1106-17, (2013)
Dose- and time-dependent effects of lipopolysaccharide on technetium-99-m-labeled diethylene-triamine pentaacetatic acid clearance, respiratory system mechanics and pulmonary inflammation. Kastis GA, Toumpanakis D, Loverdos K, et al. Exp. Biol. Med. (Maywood.) 238(2), 209-22, (2013)
Design, synthesis, and structure-activity relationship studies of novel 3-alkylindole derivatives as selective and highly potent myeloperoxidase inhibitors. Soubhye J, Aldib I, Elfving B, et al. J. Med. Chem. 56(10), 3943-58, (2013)
Acute aortocaval fistula: role of low perfusion pressure and subendocardial remodeling on left ventricular function. Mazzo FR, de Carvalho Frimm C, Moretti AI, et al. Int. J. Exp. Pathol. 94(3), 178-87, (2013)
Ethyl pyruvate significantly inhibits tumour necrosis factor-α, interleukin-1β and high mobility group box 1 releasing and attenuates sodium taurocholate-induced severe acute pancreatitis associated with acute lung injury. Luan ZG, Zhang J, Yin XH, et al. Clin. Exp. Immunol. 172(3), 417-26, (2013)
Differences in the behavior of advanced glycation end products and advanced oxidation protein products in patients with allergic rhinitis. Di Lorenzo G, Minciullo PL, Leto-Barone MS, et al. J. Investig. Allergol. Clin. Immunol. 23(2), 101-6, (2013)
Differential antioxidative response of tolerant and sensitive maize (Zea mays L.) genotypes to drought stress at reproductive stage. Chugh V, Kaur N, Grewal MS, et al. Indian J. Biochem. Biophys. 50(2), 150-8, (2013)
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|D9143||o-Dianisidine, peroxidase substrate|
|A4685||Luminol sodium salt|
|A1888||2,2′-Azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt, ≥98% (HPLC)|
|G5502||Guaiacol, oxidation indicator|
|A3537||5-Aminosalicylic acid, ≥99%|
|A4382||4-Aminoantipyrine, reagent grade|
|A8511||Luminol, ≥97% (HPLC)|
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