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M6908 Sigma

Myeloperoxidase from human leukocytes

lyophilized powder, ≥50 units/mg protein

Synonym: MPO, Peroxidase, myelo

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Description

Analysis Note

Source material tested and found negative for antibody to HIV and for HBSAG.

Other Notes

Lysosomal heme-containing protein.

Unit Definition

One unit will produce an increase in absorbance (A470) of 1.0 per min at pH 7.0 and 25 °C, calculated from the initial rate of reaction using guaiacol as substrate. Total reaction volume: 3.035 mL.

Physical form

Lyophilized from 50 mM sodium acetate buffer, pH 6.0, 0.1 M sodium chloride

Application

Myeloperoxidase (MPO) from human leukocytes has been used in MPO assay.

Biochem/physiol Actions

Myeloperoxidase (MPO) has a crucial role to play in destruction of various microorganisms and foreign cells, such as bacteria, fungi, viruses, red cells and malignant and nonmalignant nucleated cells. MPO catalyzes the production of number of reactive oxidant species (ROS) that influence tissue damage during inflammation. MPO and its downstream inflammatory pathways function as a potent therapeutic target for prophylaxis of atherosclerotic cardiovascular disease. MPO catalyze the synthesis of polychlorinated dibenzo(p)dioxins and furans (PCDD/F) from precursor such as chlorophenols in presence of hydrogen peroxide (H2O2).

General description

Myeloperoxidase (MPO) is encoded by the gene mapped to human chromosome 17q22-24. The encoded protein is a leukocyte-derived enzyme and is an integral constituent of the innate immune response. MPO belongs to the heme peroxidase superfamily. MPO is a heme protein containing iron and is highly expressed in leukocytes, neutrophils, monocytes and some subtypes of tissue macrophages.

Price and Availability

Suggested Laboratory Gloves


Laboratory GlovesThis substance has been tested against several types of hand protection for CE compliance. Click below to find the recommended gloves for handling this product.




All labs need water
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
1

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Related Content

Enzymes & Proteins

Application Index | Enzyme Index | Substrate Index | Inhibitor Index | Cofactor Index | Lectin Index
Keywords: Cell signaling, Diagnostic, Drug discovery, Molecular biology

Peer-Reviewed Papers
15

References

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inhibitor

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S2002 Sodium azide, ReagentPlus®, ≥99.5%

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92210 Timestrip Plus 0 °C
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substrate

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D9143 o-Dianisidine, peroxidase substrate
A0156 N-(4-Aminobutyl)-N-ethylisoluminol, ≥90%
A4685 Luminol sodium salt
A1888 2,2′-Azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt, ≥98% (HPLC)
G5502 Guaiacol, oxidation indicator
A1661 N-(6-Aminohexyl)-N-ethylisoluminol
A3537 5-Aminosalicylic acid, ≥99%
A4382 4-Aminoantipyrine, reagent grade
A8264 4-Aminophthalhydrazide
A5754 3-Amino-9-ethylcarbazole, ≥95%, powder
A8511 Luminol, ≥97% (HPLC)

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