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M7151 Sigma

α2-Macroglobulin from human plasma

lyophilized powder, ≥90% (electrophoresis)

Synonym: α2-M

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Properties

Related Categories α2-Macroglobulin, Biochemicals and Reagents, Plasma & Blood Proteins, Plasma, Blood, and Related Proteins and Reagents, Proteins and Derivatives More...
assay   ≥90% (electrophoresis)
form   lyophilized powder
mol wt   mol wt ~720 kDa (four glycoprotein subunits)
composition   Protein, ~20% biuret
storage temp.   −20°C
Gene Information   human ... A2M(2)

Description

Analysis Note

Plasma from each donor has been tested and found negative for antibody to HIV-1/HIV-2, antibody to HCV and HbSAg.

Application

Inhibits all classes of endoproteases by forming a complex with the protease. When the protease cleaves the macroglobulin "bait" sequence, the macroglobulin rearranges and traps the protease.

This preparation does not demonstrate protease inhibitory activity, but may be useful as a marker.

Packaging

Package size based on protein content

Physical form

Lyophilized powder containing Tris HCl, pH 8.0 and 0.1 M sodium chloride

Biochem/physiol Actions

α2-Macroglobulin is found abundantly in plasma and interstitial fluids. The protease-α2-M balance plays an important role in mediating inflammatory tissue destruction. Serum levels of α2-M and protease-α2-M complexes are increased in patients with sepsis, emphysema, periodontitis, rheumatoid arthritis, and other inflammatory diseases, and oxidant inactivation of α2-M may contribute to tissue destruction during inflammation.

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Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
2
Protocols & Articles
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M6159 α2-Macroglobulin from human plasma, BioUltra, ≥98% (SDS-PAGE)

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