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M7277 Sigma

(±)−3-(3,4-Dihydroxyphenyl)-2-methyl-DL-alanine

Synonym: 2-Methyl-3-(3,4-dihydroxyphenyl)-DL-alanine, DL-α-Methyl-DOPA

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Enzyme Inhibitors, L-Aromatic Amino Acid Decarboxylase, Neuroscience,
InChI Key   CJCSPKMFHVPWAR-UHFFFAOYSA-N
storage temp.   −20°C
Gene Information   human ... DDC(1644)

Description

Biochem/physiol Actions

Inhibitor of L-aromatic amino acid decarboxylase. Developed as an antihypertensive with a predominantly CNS site of action. It acts via its metabolite α-methylnoradrenaline and the stimulation of central α2-adrenoceptors in the brain stem, leading to peripheral sympathoinhibition and a reduction of elevated blood pressure, heart rate, and plasma catecholamines.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Legal Information

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Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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