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M7391 Sigma

Melittin from honey bee venom

≥65% (HPLC)

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Properties

Related Categories Biochemicals and Reagents, Chelators, Enzyme Inhibitors, Enzyme Inhibitors by Type, Enzymes, Inhibitors, and Substrates More...
InChI Key   VDXZNPDIRNWWCW-JFTDCZMZSA-N
assay   ≥65% (HPLC)
foreign activity   Phospholipase A2 ≤2%
storage temp.   −20°C

Description

Amino Acid Sequence

Gly-Ile-Gly-Ala-Val-Leu-Lys-Val-Leu-Thr-Thr-Gly-Leu-Pro-Ala-Leu-Ile-Ser-Trp-Ile-Lys-Arg-Lys-Arg-Gln-Gln-NH2

Biochem/physiol Actions

Binds calmodulin in a Ca2+-dependent manner; inhibits Na+-K+-ATPase.

Melittin acts as an anti-coagulating protein by increasing the time of blood clotting in vitro. Melittin inhibits the activity of S100 calcium-binding protein B (S100B) and plays a vital role in Epilepsy treatment. Melittin retard cathepsin S-induced invasion, proliferation and angiogenesis via inhibition of the vascular endothelial growth factor A (VEGF-A) /VEGF receptor 2 (VEGFR-2)/ mitogen-activated protein kinase 1 (MEK1)/ extracellular signal-regulated kinase 1/2 (ERK1/2) pathway in human MHCC97-H cells (liver cancer cells). Melittin has therapeutic application in various inflammatory diseases such as skin inflammation, neuroinflammation, atherosclerosis, arthritis and liver inflammation. Accumulated melittin degrades phospholipid packing in the cell membrane and causes cell lysis and cell death.

Other Notes

The principle hemolytic component of honeybee venom.

Application

Melittin from honey bee venom has been used to study the role of melittin in allergic reactions.

General description

Melittin is hydrophobic in nature except for a region with Lys-Arg-Lys-Arg sequence near C-terminal end. This structural characteristic makes melittin a highly surface-active and a powerful, direct haemolytic agent. The encoded protein contains 26 amino acids. Monomeric form of melittin has a molecular weight of 2,840Da and tetrameric form has molecular weight of approximately 12,500Da.

Price and Availability


Biomedical Applications
Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
UN 3462 6.1 / PGI
WGK Germany 
3
RTECS 
OS3960000
Protocols & Articles
Peer-Reviewed Papers
15

References

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92210 Timestrip Plus 0 °C
06693 Timestrip Plus -20 °C

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