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M7898 Sigma

Monoclonal Anti-Thy 1.1 antibody produced in mouse

clone TN-26, purified immunoglobulin, buffered aqueous solution

Properties

Related Categories Alphabetical Index, Analytical Cytology, Antibodies, Antibodies for Cell Biology, Antibodies for Immune Cell Signaling and Blood,
species reactivity   mouse
application(s)   complement-mediated cytotoxicity assay: 1:20,000
  indirect immunofluorescence: suitable
clone   TN-26, monoclonal
antibody form   purified immunoglobulin
form   buffered aqueous solution
isotype   IgM
shipped in   dry ice
storage temp.   −20°C
Gene Information   mouse ... Thy1(21838)
biological source   mouse
conjugate   unconjugated

Description

Immunogen

thymocytes from AKR/J (Thy 1.1) mice.

General description

Thymus cell antigen 1 (Thy 1.1) is a glycosylphosphatidyl-anchored protein. It belongs to the of the immunoglobulin superfamily. Thy 1.1 is expressed in stem cells, T-cells and neurons.

Physical form

Solution in 0.1 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Specificity

Recognizes Thy 1.1 bearing cells and is less than 5% cross-reactive with Thy 1.2 bearing cells. Titer is 1:20,000 as determined by in vitro cytotoxicity against AKR/J thymocytes.

Biochem/physiol Actions

Studies have shown that mice lacking the protein thymus cell antigen 1 (Thy 1.1) have an increased number of fibroblasts. It suppresses proliferation and enhances apoptosis in dermal fibroblasts, thereby modulating cell growth. This is carried out by regulating the action of β3 integrin.

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