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  • M7934 - Anti-Macrophage Colony Stimulating Factor Receptor antibody produced in goat

M7934 Sigma

Anti-Macrophage Colony Stimulating Factor Receptor antibody produced in goat

affinity isolated antibody, lyophilized powder

Synonym: Anti-CD115, Anti-M-CSF-Receptor



Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to Cytokines and Growth Factors, Antibodies to Hematopoietic Cytokines,
species reactivity   human
application(s)   flow cytometry: 3-10 μg
  indirect ELISA: 0.5-1.0 μg/mL
  western blot: 0.1-0.2 μg/mL
clone   polyclonal
antibody form   affinity isolated antibody
form   lyophilized powder
storage temp.   −20°C
Gene Information   human ... CSF1R(1436)
biological source   goat
conjugate   unconjugated



recombinant human macrophage colony stimulating factor receptor extracellular domain expressed in NSO cells.

General description

Macrophage Colony Stimulating Factor (M-CSF) is a cytokine that plays a crucial role in host response to viral and fungal infections. It is secreted by fibroblasts, monocytes/macrophages and epithelial cells. M-CSF has been reported to the growth and differentiation of monocytes/macrophages. The effects of M-CSF are mediated by M-CSF-receptor. The expression of M-CSF-R is restricted to cells of monocyte/macrophage lineage. M-CSF-R is also expressed in uterus and placental trophoblasts indicating its role in the development of placenta. Reports suggest that M-CSF may act in an autocrine/paracrine manner to sustain HIV replication and increase the frequency by which the macrophages become infected with the virus. Anti-Macrophage Colony Stimulating Factor Receptor antibody specifically reacts with human M-CSF-R.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.


Anti-Macrophage Colony Stimulating Factor Receptor antibody may be used for immunoblotting at a working concentration of 0.1-0.2 μg/ml. For ELISA, a working antibody concentration of 0.5-1.0 μg/ml is recommended. Flow cytometry may be performed using 3-10 μg/106 cells.

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RIDADR  NONH for all modes of transport
WGK Germany  2
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