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M7934 Sigma

Anti-Macrophage Colony Stimulating Factor Receptor antibody produced in goat

affinity isolated antibody, lyophilized powder

Synonym: Anti-CD115, Anti-M-CSF-Receptor

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to Cytokines and Growth Factors, Antibodies to Hematopoietic Cytokines,
species reactivity   human
application(s)   flow cytometry: 3-10 μg
  indirect ELISA: 0.5-1.0 μg/mL
  western blot: 0.1-0.2 μg/mL
clone   polyclonal
antibody form   affinity isolated antibody
form   lyophilized powder
storage temp.   −20°C
Gene Information   human ... CSF1R(1436)
biological source   goat
conjugate   unconjugated

Description

Immunogen

recombinant human macrophage colony stimulating factor receptor extracellular domain expressed in NSO cells.

General description

Macrophage Colony Stimulating Factor (M-CSF) is a cytokine that plays a crucial role in host response to viral and fungal infections. It is secreted by fibroblasts, monocytes/macrophages and epithelial cells. M-CSF has been reported to the growth and differentiation of monocytes/macrophages. The effects of M-CSF are mediated by M-CSF-receptor. The expression of M-CSF-R is restricted to cells of monocyte/macrophage lineage. M-CSF-R is also expressed in uterus and placental trophoblasts indicating its role in the development of placenta. Reports suggest that M-CSF may act in an autocrine/paracrine manner to sustain HIV replication and increase the frequency by which the macrophages become infected with the virus. Anti-Macrophage Colony Stimulating Factor Receptor antibody specifically reacts with human M-CSF-R.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.

Application

Anti-Macrophage Colony Stimulating Factor Receptor antibody may be used for immunoblotting at a working concentration of 0.1-0.2 μg/ml. For ELISA, a working antibody concentration of 0.5-1.0 μg/ml is recommended. Flow cytometry may be performed using 3-10 μg/106 cells.

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