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M8663 Sigma

Monoclonal Anti-Monocyte Chemotactic Protein-3 antibody produced in mouse

clone 36320.11, purified immunoglobulin, lyophilized powder

Synonym: Anti-MCP-3

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies for Hematopoietic Stem Cells, Antibodies for Stem Cell Biology,
species reactivity   human
application(s)   indirect ELISA: suitable
  neutralization: suitable
  western blot: suitable
clone   36320.11, monoclonal
antibody form   purified immunoglobulin
form   lyophilized powder
isotype   IgG1
storage temp.   −20°C
Gene Information   human ... CCL7(6354)
biological source   mouse
conjugate   unconjugated

Description

Immunogen

recombinant human MCP-3.

General description

Monocyte Chemotactic Protein-3 (MCP-3) belongs to a family of C-C chemotactic cytokines. MCP-1, -2, -4, and -5 are the other five monocyte chemo attractants identified. The MCP cytokines are involved in recruitment of leukocytes to the sites of inflammation, and activate NK cells and CD4+ and CD8+ T lymphocytes. Additionally, MCP cytokines can activate basophils to secrete histamines and also attract eosinophils. MCPs play an important role in pathological conditions such as systemic sclerosis, myocardia and cardiac ischemia. Monoclonal Anti-Monocyte Chemotactic Protein-3 antibody specifically reacts with human MCP-3 (CCL7). It does not react with human MCP-1 or MCP-2.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.

Specificity

Neutralizes the biological activity of recombinant human MCP-3. Does not cross-react with recombinant human MCP-1 or MCP-2.

Preparation Note

Purified using protein G.

Application

Anti-monocyte chemotactic protein 3 antibody may be used in ELISA at a concentration of 0.5-1.0 μg/ml. For immunoblotting a working concentration of 0.1-0.2 μg/ml may be used. The antibody is suitable for neutralization reactions.

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