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  • M8683 - Anti-Matrix Metalloproteinase-7, N-Terminal of Catalytic Zinc Site antibody produced in rabbit

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M8683 Sigma

Anti-Matrix Metalloproteinase-7, N-Terminal of Catalytic Zinc Site antibody produced in rabbit

~1 mg/mL, affinity isolated antibody, buffered aqueous glycerol solution

Synonym: Anti-MMP-7

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to Extracellular Matrix, Antibodies to Matrix Metalloproteinases and TIMPs,
species reactivity   human
application(s)   immunohistochemistry: suitable
  immunoprecipitation: suitable
  indirect ELISA: suitable
  western blot: 1:1,000
clone   polyclonal
concentration   ~1 mg/mL
antibody form   affinity isolated antibody
form   buffered aqueous glycerol solution
mol wt   antigen (active form) mol wt 18 kDa (reduced)
  antigen (pro-form) mol wt 28 kDa
shipped in   wet ice
storage temp.   −20°C
Gene Information   human ... MMP7(4316)
biological source   rabbit
conjugate   unconjugated

Description

Immunogen

synthetic peptide corresponding to the N-terminal end of the catalytic zinc site of human matrix metalloproteinase-7 (matrilysin, PUMP).

General description

Matrix metallopeptidase 7 (MMP-7) is also known as matrilysin and expressed in tumor cells. It possesses many α-helices and β-sheets, with an active domain. The gene is localized on human chromosome 11q21-q22.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 50% glycerol and 15 mM sodium azide.

Specificity

Reacts with reduced and non-reduced MMP-7.

Application

Anti-matrix metalloproteinase-7, N-terminal of catalytic zinc site antibody produced in rabbit has been used in immunohistochemistry and Western blotting.

Biochem/physiol Actions

Matrix metallopeptidase 7 (MMP-7) is a proteolytic enzyme which acts on fibronectin, laminin and collagen type IV. It can also activate other metalloproteinases like MMP-2 and MMP-9. MMP-7 plays an important role in the growth of cancerous cells.

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