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  • M9426 - MAP Kinase, N-terminal histidine-tagged non-activated protein from rat

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M9426 Sigma

MAP Kinase, N-terminal histidine-tagged non-activated protein from rat

≥95% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, 500 U/mg (Can be activated by MEK to more than 500 units per mg)

Synonym: ERK2, Extracellular-signal regulated kinase, MAPK, Mitogen activated protein kinase

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Properties

Related Categories Application Index, Biochemicals and Reagents, Cell Biology, Cell Signaling Enzymes, Cell Signaling and Neuroscience,
recombinant   expressed in E. coli
assay   ≥95% (SDS-PAGE)
form   lyophilized powder
mol wt   mol wt 42 kDa
storage temp.   −20°C
Gene Information   rat ... Mapk1(116590)

Description

Biochem/physiol Actions

MAP kinase is a serine/threonine kinase that is activated by MEK through a phosphorylation cascade. The cascade starts with extracellular signals transmitted by growth factor-regulated receptor tyrosine kinases or G-protein coupled receptors. Dually phosphorylated (Thr and Tyr) MAP kinase translocates from the cytoplasm to the nucleus, where it phosphorylates protein transcription factors, transducing extracellular signals into genomic responses, proliferation or differentiation.

Packaging

0.1 mg in glass bottle

Unit Definition

One unit of activated MAP kinase will transfer 1 nmol of phosphate from ATP to myelin basic protein per min at 30 °C.

Physical form

Lyophilized powder containing Tris, pH 7.5, NaCl, and EGTA, with DTT and trehalose as stabilizers

Price and Availability

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
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