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M9432 Sigma

Anti-Macrophage Inflammatory Protein-2, Viral antibody produced in goat

affinity isolated antibody, lyophilized powder

Synonym: Anti-MIP 2, Viral

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to Chemokines, Antibodies to Cytokines and Growth Factors,
biological source   goat
antibody form   affinity isolated antibody
clone   polyclonal
form   lyophilized powder
species reactivity   viral
application(s)   indirect ELISA: 0.5-1.0 μg/mL
  western blot: 0.1-0.2 μg/mL
conjugate   unconjugated
storage temp.   −20°C

Description

Immunogen

recombinant viral MIP 2, expressed in E. coli.

Specificity

The antibody will recognize recombinant viral MIP-2. The antibody shows <10% cross-reactivity with recombinant viral MIP-1 and recombinant human MIP-1β.

Physical form

Lyophilized from a 0.2 μm-filtered solution in phosphate-buffered saline.

Application

Anti-Macrophage Inflammatory Protein-II (MIP-II) antibody may be used in immunoblotting at a working concentration of 0.1-0.2 μg/ml. For ELISA the recommended concentration is 0.5-1.0 μg/ml.

General description

The genome of Kaposi’s sarcoma-associated herpes virus (KSHV) encodes two gene products that are similar to the sequence of human chemokine, MIP-1α. These are named according to the human protein counterpart as viral macrophage inflammatory protein (vMIP)-I and –II. The sequence identity of vMIP-I and vMIP-II to human MIP-1α is 37.9% and 41.1%, respectively. The expression of vMIP-1 and vMIP-2 are reportedly induced by phorbol esters in latently infected lymphoma cells. Both vMIP-I and vMIP-II partially inhibit the infection of peripheral blood mononuclear cells by HIV. vMIP-II also reportedly blocks the infection of CD4-positive cell line expressing CCR3 by HIV, type-1
Anti-Macrophage Inflammatory Protein-II (MIP-II) recognizes recombinant viral MIP-II. The antibody shows less than 10% cross reactivity with recombinant viral MIP-I and recombinant human MIP-1b.

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Safety & Documentation

Safety Information

Safety Information for this product is unavailable at this time.
Protocols & Articles

Articles

Antibody Basics

Immunoglobulins (Igs) are produced by B lymphocytes and secreted into plasma. The Ig molecule in monomeric form is a glycoprotein with a molecular weight of approximately 150 kDa that is shaped more ...
Keywords: Affinity chromatography, Centrifugation, Chromatography, Digestions, Direct immunofluorescence, Gene expression, High performance liquid chromatography, Immunofluorescence, Ion Exchange, Microscopy, Precipitation, Purification, Rheumatology, Scanning electron microscopy

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Peer-Reviewed Papers
15

References

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M5539 Anti-Macrophage Inflammatory Protein-2 antibody produced in goat, affinity isolated antibody, lyophilized powder

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