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M9434 Sigma

Monoclonal Anti-Myelin Basic Protein (MBP) (36-50) antibody produced in rat

clone 14, tissue culture supernatant

Synonym: Anti-MBP

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies for Neural Stem Cells, Antibodies for Neurobiology,
species reactivity   bovine, guinea pig, human, sheep, rabbit (weak)
application(s)   immunohistochemistry: suitable
  indirect ELISA: suitable
clone   14, monoclonal
antibody form   tissue culture supernatant
isotype   IgG
contains   0.09% sodium azide
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... MBP(4155)
biological source   rat
conjugate   unconjugated

Description

Immunogen

bovine myelin basic protein.

General description

Myelin basic protein (MBP) is part of the myelin sheath and is a calcium-dependent protein. It has six isoforms and the gene encoding it is localized on human chromosome 18q23.

Specificity

Recognizes amino acids 36-50 of myelin basic protein.

Preparation Note

Generated by somatic cell hybridization of NS0 myeloma cells with spleen cells from an outbred rat immunized with bovine myelin basic protein.

Biochem/physiol Actions

Myelin basic protein (MBP) associates with calmodulin and has been identified as an auto-antigen in multiple sclerosis (MS). It also inhibits the assembly of amyloid-β protein.

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