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  • M9558 - Anti-Muscarinic Acetylcholine Receptor (M2) antibody produced in rabbit

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M9558 Sigma

Anti-Muscarinic Acetylcholine Receptor (M2) antibody produced in rabbit

affinity isolated antibody

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Neurotransmission, Antibodies to Neurotransmitter Receptors, MUE-MZ,
species reactivity   human, mouse, rat
application(s)   immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
  immunoprecipitation: suitable
  western blot (chemiluminescent): 1:200 using brain membranes
clone   polyclonal
antibody form   affinity isolated antibody
storage temp.   −20°C
Gene Information   human ... CHRM2(1129)
mouse ... Chrm2(243764)
rat ... Chrm2(81645)
biological source   rabbit
conjugate   unconjugated

Description

Immunogen

GST fusion protein of a part of the i3 intracellular loop of human M2 muscarinic acetylcholine receptor (mAChR) corresponding to amino acid residues 227-356.1, 2

General description

Muscarinic acetylcholine receptor M2 is expressed in the heart and many other tissues. The gene encoding it is localized on human chromosome 7.

Physical form

Lyophilized at ~0.3 mg/ml from a solution of phosphate-buffered saline, pH 7.4, containing 1% bovine serum albumin, and 0.05% sodium azide.

Biochem/physiol Actions

Muscarinic acetylcholine receptor M2 plays an important role in regulating functions of the heart and activities like pain perception and cognition. It is regarded as a good model in GPCR (G protein-coupled receptor) biology pharmacological studies. This receptor has a function in airway remodeling and it enhances the proliferation of airway smooth muscle cells (ASM) which is induced by transforming growth factor-β (TGF-β).

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