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M9756 Sigma

Methylcobalamin

vitamin B12 analog

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Properties

Related Categories Biochemicals and Reagents, Vitamin B, Vitamin B12, Vitamins
InChI Key   JEWJRMKHSMTXPP-WYVZQNDMSA-L
storage temp.   −20°C

Description

Packaging

1 g in poly bottle

100, 250 mg in poly bottle

25 mg in glass insert

Application

Methylcobalamin has been used for the preparation of standard solution to serum vitamin B12 in automated competitive protein binding (CPB) assays.

Biochem/physiol Actions

Vitamin B12 (cobalamin) refers to a group of chemically-related cobalt containing molecules involved in cell processes such as DNA synthesis, fatty acid synthesis, energy production and regulation. The physiologically active forms of vitamin B12 include methylcobalamin and adenosylcobalamin, whereas hydroxocobalamin (vitamin B12a, OHCbl) and cyanocobalamin (CNCbl) are storage and delivery forms. Bacteria-derived hydroxocobalamin (OHCbl) and CNCbl are converted in humans to useful coenzyme forms to support metabolic processes such as mitochondrial methylmalonylcoenzyme A mutase conversion of methylmalonic acid (MMA) to succinate to link lipid and carbohydrate metabolism, and activation of methionine synthase, the rate limiting step in the synthesis of methionine.

General description

Methylcobalamin is the activated analog of vitamin B12, and differs from vitamin B12 in that it contains a methyl group instead of a cyanide group. It functions as a coenzyme of methionine synthase which is essential for the conversion of homocysteine to methionine in the methylation cycle.

Price and Availability

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
2
RTECS 
GG3745000

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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92210 Timestrip Plus 0 °C
06693 Timestrip Plus -20 °C

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