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M9794 Sigma

6-Maleimidohexanoic acid N-hydroxysuccinimide ester

≥98%, powder

Synonym: 6-Maleimidocaproic acid N-succinimidyl ester, N-(ε-Maleimidocaproyloxy)succinimide, N-Succinimidyl 6-maleimidocaproate, EMCS

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Properties

Related Categories Amine to Sulfhydryl, Chemical Biology, Chemical Synthesis, Crosslinkers, Crosslinking,
InChI Key   VLARLSIGSPVYHX-UHFFFAOYSA-N
assay   ≥98%
form   powder
mp   70-73 °C(lit.)
solubility   chloroform: soluble100 mg/mL
  DMF: soluble (lit.)(lit.)
storage temp.   −20°C

Description

Application

A heterobifunctional cross-linking reagent incorporating an extended spacer with amine and sulfhydryl reactivity. Typically, coupled initially to molecules containing primary amines by amide bonds buffered at pH 7.5 (6.5-8.5) The second coupling is specific for molecules containing free sulfhydryl by thioether linkage buffered at pH 6.8 (6.5-7.0). Useful for preparation of enzyme immunoconjugates and hapten carrier molecule conjugates. Contains 9 atom linker. An extended aliphatic spacer stabilizes the maleimide prior to coupling compared to aromatic spacers.

Packaging

10 mg in glass insert

25, 100 mg in glass bottle

Price and Availability


Amplified Detection
Safety & Documentation

Safety Information

Symbol 
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles
Peer-Reviewed Papers
15

References

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