• USA Home
  • MIRNA - MISSION® miRNA Product Offerings

EMAIL THIS PAGE TO A FRIEND
MIRNA Sigma

MISSION® miRNA Product Offerings

Synonym: Custom miRNA, Human miRNA cDNA Library, Lenti TuDs, Lentiviral miRNA mimics, MISSION® 3′UTR Lenti GoClone, MISSION® Lentiviral miRNA inhibitors, MISSION® LightSwitch Luciferase Assay Reagent, MISSION® Target ID Library, MISSION® miRNA Human inhibitors, MISSION® miRNA Human mimics, MISSION® miRNA Workflow, Synthetic TuDs, Synthetic miRNA inhibitors, Synthetic miRNA mimics, Tough Decoy Design, miRBase version 21, miRNA Identification, miRNA Library, miRNA Screening, miRNA Validation

 Visit the Functional Genomics learning center to read and learn more about our entire gene knockdown, knockout and expression portfolio
Learning Center

miRNA Synthetic Mimics

Human miRNA mimics based on miRBase version 21
Sigma.com/miRNAmimics


  • Human miRNA mimics available in mirBase ver. 21
  • Ready for transfection
  • Unique design significantly reduces possible sense strand off-target effects
  • Available as a complete library or individual miRNA mimics
  • Custom miRNA mimic synthesis capabilities: custom species sequences, quantities, and modifications

miRNA Lentiviral Mimics

Choose from over 2500+ miRNA mimics


  • Most comprehensive collection of miRNA human mimics available (mirBase ver. 21)
  • Available as a complete library or individual miRNA mimics
  • Stable, long-term expression of miRNA
  • Efficient delivery of mimic into wide variety of cell types
  • The ability to select for cells that express the miRNA of interest
  • Custom options available
  • Learn More

Lentiviral Library- Request A quote


  • Gene family sets are fully customizable allowing for complete flexibility to add or delete clone or gene content.

miRNA Synthetic Inhibitors

Most comprehensible list of miRNA mimics
Sigma.com/miRNAinhibitors


  • Designed using a proprietary algorithm based upon the Tough Decoy (TuD) design
  • Long-lasting inhibition at very low nM concentrations
  • Excellent resistance to cellular nucleases
  • Structure provides potent inhibition of the desired miRNA
  • Custom synthesis capabilities: custom species sequences, quantities, and modifications

miRNA Lentiviral Inhibitors

Choose from over 3,000+ human and mouse miRNA inhibitors


  • Designed using a proprietary algorithm based upon the Tough Decoy (TuD) design
  • Allows for potent inhibition of the desired miRNA
  • Stable, long-term expression of miRNA
  • Efficient delivery of mimic into wide variety of cell types
  • Species include both human and mouse: 1,953 human lenti miRNA inhibitors and 1,214 mouse lenti miRNA inhibitors
  • Custom options available
  • Learn More

Create your own Panel
Different gene pathway of interest? Want a more complete list?
Submit a request below.


    Target ID miRNA

    Bench-top transcriptome-wide human miRNA and ncRNA gene target identification.


    • Convenience: Perform dual screening with one vector due to the innovative dual selection cassette
    • Simplicity: 3 easy steps: Library Transfection, microRNA Transfection and Ganciclovir Selection, and PCR and Sequencing.
    • Relevance: The only method for genome-wide functional identification of miRNA targets
    • Custom miRNA mimic synthesis capabilities: custom species sequences, quantities, and modifications

    Lenti GoClones miRNA

    Validate miRNA targets and study post-transcriptional gene regulation with lentiviral 3′UTR reporters.


    • A genome-wide collection of pre-cloned reporter constructs for over 10,000 human 3’UTRs
    • Constructs are composed of a human 3’UTR fused to a novel luciferase reporter
    • Relevance: The only method for genome-wide functional identification of miRNA targets
    • Optimized Renilla luciferase delivers higher activity
    • System utilizes a lentiviral vector for delivery into difficult to transfect cell lines, including differentiated and non-dividing cells
    • Superb virus quality delivers superior performance
    • Negative controls, miRNA Mimics, and MISSION LightSwitch Luciferase Assay Reagent™ are available to complete the validation workflow.

    Custom miRNA

    Fully customizable miRNA sequence, vector, and lentiviral manufacturing.
    Sigma.com/customcloning


    • Customize your miRNA sequence
    • Eliminate tedious cloning and viral production
    • Service includes: miRNA design, cloning, sequence verification, DNA quantitation and titer determination
    • Custom Capabilities: Bringing you more flexibility

      miRNA Controls

      Lentiviral and Synthetic miRNA Negative Controls
      Measure transduction efficiency or monitor off-target effects.


      • All miRNA mimic and inhibitor negative controls are carefully selected, and have no known homology to known human or mouse gene sequences
      • Each negative control contains either a Arabidopsis thaliana sequence (Control 1) or a Caenorhabditis elegans sequence (Control 2)
      • Lenti TuD Negative controls available: HLTUD001C and HLTUD002C
      • Lenti miR Negative Controls available: NCLMIR001 and NCLMIR002
      • Synthetic miRNA mimics Negative Controls available as HMC0002 and HMC0003
      • Synthetic miRNA Inhibitors Negative Controls available as NCSTUD001 and NCSTUD002

      Technical Service:

      Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

      Bulk Ordering & Pricing:

      Need larger quantities for your development, manufacturing or research applications?