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  • N0149 - Anti-NIK (NF-κB Inducing Kinase) antibody produced in rabbit

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N0149 Sigma

Anti-NIK (NF-κB Inducing Kinase) antibody produced in rabbit

1 mg/mL, IgG fraction of antiserum, buffered aqueous solution

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies for Kinase/Phosphatase Biology, NE-NI,
species reactivity   human
application(s)   western blot: 1-2 μg/mL
clone   polyclonal
concentration   1 mg/mL
antibody form   IgG fraction of antiserum
form   buffered aqueous solution
mol wt   antigen mol wt 110 kDa
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... MAP3K14(9020)
biological source   rabbit
conjugate   unconjugated

Description

Immunogen

synthetic peptide corresponding to amino acids 931-947 of the C-terminal of human NIK.

General description

The nuclear factor-κB family of transcription factors comprises of five members p65 (Rel A), p105/p50, RelB, p100/p52 and c-Rel. These transcription factors regulate the expression of genes that modulate immune response, cell death and survival in response to external stimuli IL-1, TNF-α, LPS and other mitogens. Activation of NF-κB proteins proceeds either by the canonical or by the non-canonical pathway. NF-κB inducing kinase (NIK) is the central component of the non-canonical pathway that involves processing of p100. NIK stimulates the phosphorylation, ubiquitination and processing of p100 and promotes the binding of IKKα to p100. Knockout of NIK in mice blocks the processing of p100 but has no effect on TNFα-induced NF-κB activation.
Anti-NIK antibody produced in rabbit specifically recognizes human NIK (110 kDa).

Application

The antibody may be used for detection of NIK in total K562 lysate at a working concentration of 1-2 μg/mL.

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