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N0274 Sigma

Anti-Neurturin antibody produced in rabbit

~0.5 mg/mL, affinity isolated antibody

Synonym: Anti-NRTN, Anti-NTN

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies for Kinase/Phosphatase Biology, Antibodies to Cytokines and Growth Factors,
species reactivity   human
application(s)   western blot: 1:500 using a human HeLa cell lysate
clone   polyclonal
concentration   ~0.5 mg/mL
antibody form   affinity isolated antibody
mol wt   antigen mol wt 14 kDa
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... NRTN(4902)
biological source   rabbit
conjugate   unconjugated

Description

Immunogen

synthetic peptide corresponding to amino acids 178-193 of human neurturin.

General description

Neurturin (NTN) belongs to a novel class of glial-derived neurotrophic factors that have neuroprotective and neuroregenerative effects. NTN promotes the survival of neurons in central and peripheral nervous by signaling via the receptor GFRα2 and a transmembrane tyrosine kinase, Ret. The pathways through which NTN produces effects on parasympathetic neurons are MAPK, PI3K and CREB-mediated signaling. NTN plays a major role in the development and maintenance of postganglionic parasympathetic neurons. The functions of NTN include regulation of spermatogenesis, kidney morphogenesis and control of smooth muscle of penile blood vessels and several intrapelvic organs, especially urogenital organs. Anti-Neurturin recognizes human neurturin.

Application

Anti-Neurturin antibody may be used for immunoblotting at a working antibody dilution of 1:500 using whole HeLa cell lysate.

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Monoclonal and polyclonal primary antibodies are focused on cell biology, neurobiology and molecular biology. Secondary antibodies targeting multiple host’s IgG are conjugated to alkaline phosphatase...
Keywords: Amplification, Buffers, Cell biology, Enzyme-linked immunosorbent assay, Immunofluorescence, Immunohistochemistry, Inflammation, Molecular biology, Phosphorylations, Purification, Western blot

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