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N0399 Sigma

Anti-Nix antibody produced in rabbit

1 mg/mL, affinity isolated antibody, buffered aqueous solution

Synonym: Anti-BNIP3α, Anti-BNIP3L

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Apoptosis, Antibodies for Cell Biology, Antibodies to Bcl-2 Family Proteins,
species reactivity   human, mouse
application(s)   western blot: 0.5-1 μg/mL using a K562 cell lysate.
clone   polyclonal
concentration   1 mg/mL
antibody form   affinity isolated antibody
form   buffered aqueous solution
mol wt   antigen mol wt 38 kDa
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... BNIP3L(665)
mouse ... Bnip3l(12177)
biological source   rabbit
conjugate   unconjugated

Description

Immunogen

synthetic peptide corresponding to amino acids 77-92 of an internal domain of human Nix. This peptide is identical in mouse.

General description

BCL2/adenovirus E1B 19kDa interacting protein 3-like (BNIP3L) is expressed in the outer membrane of mitochondria. The BNIP3L gene is localized on human chromosome 8p21.

Biochem/physiol Actions

BCL2/adenovirus E1B 19kDa interacting protein 3-like (BNIP3L) associates with proteins which are anti-apoptotic, like B-cell lymphoma 2 (Bcl-2). It also takes part in the growth of the erythroid lineage. Expression of BNIP3L is downregulated in lung cancer cells in vitro.

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