|Related Categories||Approved Therapeutics/Drug Candidates, Bayer, Bioactive Small Molecules, Calcium Channel Modulators, Cell Biology,|
|solubility||methanol: soluble62.5 mg/mL|
45% (w/v) aq 2-hydroxypropyl-β-cyclode|
human ... ADORA3(140), CACNG1(786)|
rat ... Adora1(29290), Adora2a(25369)
Potent L-type Ca2+ channel antagonist.
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. N149.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.
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BioFiles v7 n5, 2012, 5–20
Keywords: AGE, Antihypertensives, Cardiovascular, Clinical, Diuretics, Pharmaceutical, Reductions
The voltage-gated calcium channels constitute one group of a superfamily of ion channels that also includes sodium and potassium channels and amongst which exists functional, sequence and topological...
Keywords: Cardiovascular, Clinical, Diabetes, Gene expression, Hormones, Ligands, Neurotransmitters
Temperature-sensitive Cav1.2 calcium channels support intrinsic firing of pyramidal neurons and provide a target for the treatment of febrile seizures. Radzicki D, Yau HJ, Pollema-Mays SL, et al. J. Neurosci. 33(24), 9920-31, (2013)
Slow and continuous delivery of a low dose of nimodipine improves survival and electrocardiogram parameters in rescue therapy of mice with experimental cerebral malaria. Martins YC, Clemmer L, Orjuela-Sánchez P, et al. Malaria Journal 12, 138, (2013)
Surgical treatment of ruptured anterior circulation aneurysms: comparison of pterional and supraorbital keyhole approaches. Chalouhi N, Jabbour P, Ibrahim I, et al. Neurosurgery 72(3), 437-41; discussion 441-2, (2013)
L-type calcium channel blockade alleviates molecular and reversal spatial learning and memory alterations induced by entorhinal amyloid pathology in rats. Gholamipour-Badie H, Naderi N, Khodagholi F, et al. Behav. Brain Res. 237, 190-9, (2013)
Determination of limonin in dog plasma by liquid chromatography-tandem mass spectrometry and its application to a pharmacokinetic study. Liu SJ, Zhou L, Zhang J, et al. Biomed. Chromatogr. 27(4), 515-9, (2013)
Translational potential of preclinical trials of neuroprotection through pharmacotherapy for spinal cord injury. Tator CH, Hashimoto R, Raich A, et al. J. Neurosurg. Spine 17(1 Suppl), 157-229, (2012)
The effect of nimodipine on memory impairment during spontaneous morphine withdrawal in mice: Corticosterone interaction. Vaseghi G, Rabbani M, and Hajhashemi V Eur. J. Pharmacol. 695(1-3), 83-7, (2012)
Effects of nimodipine on cerebral vasospasm in patients with aneurysmal subarachnoid hemorrhage treated by endovascular coiling. Mijailovic M, Lukic S, Laudanovic D, et al. Adv. Clin. Exp. Med. 22(1), 101-9, (2013)
Nimodipine, a calcium channel blocker, delays the spontaneous LH surge in women with regular menstrual cycles: a prospective pilot study. Nayot D, Klachook S, and Casper RF Reprod. Biol. Endocrinol. 11, 7, (2013)
Local delivery of nimodipine by prolonged-release microparticles-feasibility, effectiveness and dose-finding in experimental subarachnoid hemorrhage. Hänggi D, Perrin J, Eicker S, et al. PLoS ONE 7(9), e42597, (2012)
Biochemical, histopathological and clinical evaluation of delayed effects caused by methamidophos isoforms and TOCP in hens: ameliorative effects using control of calcium homeostasis. Emerick GL, Ehrich M, Jortner BS, et al. Toxicology 302(1), 88-95, (2012)
The impact of nimodipine administration combined with nerve-muscle pedicle implantation on long-term denervated rat thyroarytenoid muscle. Nishimoto K, Kumai Y, Sanuki T, et al. Laryngoscope 123(4), 952-9, (2013)
Reversible cerebral vasoconstriction syndrome: treatment with multiple sessions of intra-arterial nimodipine and angioplasty. Ioannidis I, Nasis N, Agianniotaki A, et al. Interv. Neuroradiol. 18(3), 297-302, (2012)
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