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N1517 Sigma

N-Nitroso-N-methylurea

ISOPAC®

Synonym: MNU, N-Methyl-N-nitrosourea

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Properties

Related Categories Cancer Research, Carcinogens, Cell Biology More...
InChI Key   ZRKWMRDKSOPRRS-UHFFFAOYSA-N
storage temp.   2-8°C

Description

Frequently Asked Questions

Frequently Asked Questions are available for this Product.

Biochem/physiol Actions

DNA alkylating agent that is carcinogenic in many animal species. Although it can induce benign and malignant tumors in most organs, MNU is most often used to model mammary tumor initiation and progression.

Caution

Injecting any compatible solvent directly into the vial permits preparation of any desired strength solution without exposure.

Packaging

1 g in serum bottle

Packaged in a 100 mL serum bottle with butyl rubber stopper and aluminum tear seal.

Reconstitution

Dissolving the contents in 100 mL of solvent yields a 1% solution.

Legal Information

Isopac is a registered trademark of Sigma-Aldrich Co. LLC

Price and Availability


All labs need water
Safety & Documentation

Safety Information

Documents

Certificate of Analysis

Certificate of Origin

Frequently Asked Questions

Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis. These documents are located on the product detail page under Useful Links & Tools. Click on the following link to search for a Certificate of Analysis. Please click the following link to see the details on our Product Dating Information.
How do I get lot-specific information or a Certificate of Analysis?
A Certificate of Analysis is available by lot number and can be obtained through our Advanced Search Option: http://www.sigmaaldrich.com/catalog/AdvancedSearchPage.do
What is the purity of N-Nitroso-N-methylurea - ISOPAC®, Product N1517?
Product No. N1517 is not assayed for purity.
Is N-Nitroso-N-methylurea - ISOPAC®, Product N1517, hazardous material?
Yes, N-Nitroso-N-methylurea (MNU) is extremely hazardous. It is a known carcinogen. N1517 is packaged as an ISOPAC so that the material does not need to weighed out. Any precautions that one can take to minimize handling the material would be advisable.
What is N-Nitroso-N-methylurea - ISOPAC®, Product N1517, soluble in?
Dissolving the contents in 100 mL of solvent yields a 1% solution. We would recommend using either ethanol or DMSO as the solvent. MNU has very poor stability in aqueous solutions.
The package size of N-Nitroso-N-methylurea - ISOPAC®, Product N1517, is 1 gram (N1517-1G), but I see that this product also contains acetic acid and water. How much of each is in the bottle?
Each bottle contains 1 gram of MNU. There is a significant amount of acetic acid and water present; the specific quantities are given on the certificate of analysis of each lot. Including the acetic acid and water, the total amount of material in each bottle will typically be in the 1-2 gram range.
How do I find price and availability?
There are several ways to find pricing and availability for our products.  Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers. 
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS. To access the shipping information for this material, use the link on the product detail page for the product, or search here. 
My question is not addressed here, how can I contact Technical Service for assistance?
Use the option to the right to "Ask a Question" by email of a Technical Service Scientist.
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Protocols & Articles

Articles

Carcinogenesis and Epigenetics

Cancer research has revealed that the classical model of carcinogenesis, a three step process consisting of initiation, promotion, and progression, is not complete. The expansion of the carcinogenesi...
Vicki Caligur
BioFiles 2008, 3.5, 18.
Keywords: Acetylations, Adhesion, Alkylations, Apoptosis, Biofiles, Cancer, Carcinogens, Cell division, Cell proliferation, Cell signaling, DNA microarrays, Drug discovery, Environmental, Epigenetics, Events, Gene expression, Genetic, Hormones, Metabolism, Methylations, Microarray Analysis, Mutagens, PAGE, Recombination, Reductions, Sequences, Transcription, Type, transformation

DNA Damage and Repair

Damage to cellular DNA is involved in mutagenesis and the development of cancer. The DNA in a human cell undergoes several thousand to a million damaging events per day, generated by both external (e...
Keywords: AGE, Alkylations, Apoptosis, Biochemistry, Cancer, Carcinogens, Catalysis, Clinical, DNA replication, Deaminations, Degradations, Eliminations, Environmental, Enzymology, Gene expression, Genetic, Infrared spectroscopy, Metabolites, Methylations, Mutagens, Oncology, Oxidations, Polymorphisms, Rearrangements, Recombination, Substitutions, Transcription, transformation

Peer-Reviewed Papers
15

References

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