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N1628 Sigma

Novobiocin sodium salt

≥90% (HPLC)

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Properties

Related Categories Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics N-S, Antibiotics by Application,
assay   ≥90% (HPLC)
solubility   H2O: soluble50 mg/mL
Mode of action   DNA synthesis | interferes
  enzyme | inhibits
antibiotic activity spectrum   Gram-positive bacteria
storage temp.   2-8°C

Description

Application

For the production of positively supercoiled plasmid DNA. Inhibitor of bacterial DNA gyrase and eukaryotic DNA topoisomerase. Inhibitor of retrovirus RNA-dependent DNA-polymerase.

Novobiocin, an inhibitor of Hsp90, is used to study heat shock protein inhibition and to produce positively supercoiled plasmid DNA.

Biochem/physiol Actions

Mode of Action: Inhibits DNA synthesis by inhibiting the enzyme Topoisomerase II.
Antimicrobial spectrum: Gram-positive bacterial.

Novobiocin inhibits DNA synthesis by inhibiting the GyrB subunit of the Topoisomerase enzyme involved in energy transduction. Novobiocin acts as a competitive inhibitor of the ATPase reaction catalysed by GyrB.

Packaging

1, 5, 25, 100 g in glass bottle

Other Notes

Stored in frozen aliquots,Keep container tightly closed in a dry and well-ventilated place.Light sensitive

Protocols & Applications

Antibiotic Selector for application, solubility, solution stability, working concentration, and mode of action information

Price and Availability


Laboratory Gloves
Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
2
RTECS 
RD5425000
Protocols & Articles
Peer-Reviewed Papers
15

References

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