|Related Categories||B, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience,|
|Gene Information||human ... OPRK1(4986)|
Potent and highly selective κ opioid receptor antagonist.
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solid, ≥98% (HPLC)
≥98% (TLC and titration), powder
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Opioid receptors are distributed widely in brain and found in spinal cord and peripheral sensory and autonomic nerves. There are three well-characterized members of the opioid receptor family, design...
Chemical neuroanatomical and psychopharmacological evidence that κ receptor-mediated endogenous opioid peptide neurotransmission in the dorsal and ventral mesencephalon modulates panic-like behaviour. da Silva JA, de Freitas RL, Eichenberger GC, et al. Eur. J. Pharmacol. 698(1-3), 235-45, (2013)
Stress produces aversion and potentiates cocaine reward by releasing endogenous dynorphins in the ventral striatum to locally stimulate serotonin reuptake. Schindler AG, Messinger DI, Smith JS, et al. J. Neurosci. 32(49), 17582-96, (2012)
Effects of κ- and μ-opioid agonists on cholinergic neurotransmission and contraction in isolated bovine trachealis. Baroffio M, Crimi E, Rehder K, et al. Respir. Physiol. Neurobiol. 185(2), 281-6, (2013)
Elucidation of the mechanisms of membranotropic effects of RU-1203 on ionic channels of Lymnaea stagnalis neurons. Grechko OY, Spasov AA, Vislobokov AI, et al. Bull. Exp. Biol. Med. 153(3), 301-4, (2012)
Dysregulation of kappa-opioid receptor systems by chronic nicotine modulate the nicotine withdrawal syndrome in an age-dependent manner. Tejeda HA, Natividad LA, Orfila JE, et al. Psychopharmacology 224(2), 289-301, (2012)
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