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N1780 Sigma

Neurotrophin-4 human

recombinant, expressed in baculovirus infected Sf21 cells, lyophilized powder, suitable for cell culture, >97% (SDS-PAGE)

Synonym: NT-4, NTF4

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Description

Analysis Note

The biological activity is measured in a cell proliferation assay using a TrkB-transfected cell line BaF-TrkB-BD.

Biochem/physiol Actions

Neurotrophin-4 (also called NT-4/5 or NT-5) is a 14 kDa member of the neurotrophin family. NT-4 shares 95% sequence homology between human and rat. NT-4 from human, rat, and Xenopus are active on chick dorsal root ganglia. NT-4 is expressed in many tissues and major brain regions. NT-4 promotes survival and differentiation of various cells in culture including spinal neuons, basal forebrain cholinergic neurons, hippocampal neurons, cerebellar granule cells, embryonic dopaminergic neruons of mesencephalon, noradrenergic neurons of the locus coeruleus, dopaminergic, GABAergic, and serotoninergic neurons of the substantia nigra, and embryonic trigeminal and jugular neurons.

Physical form

Lyophilized from a 0.2 μm filtered solution in 30% acetonitrile and 0.1% TFA, containing 50 μg bovine serum albumin per 1 μg of cytokine.

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Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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