Neuraminidase from Clostridium perfringens (C. welchii)
Type X, lyophilized powder, ≥50 units/mg protein (using NAN-lactose)
DOWNLOAD MSDS (PDF)Synonym: Acyl-neuraminyl Hydrolase, Receptor-destroying enzyme, Sialidase
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CAS Number 9001-67-6
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EC Number 232-624-6
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MDL number MFCD00131711
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Popular Documents: Product Information Sheet (PDF)
| Properties
| Related Categories | 3.2.x.x Glycosidases, 3.x.x.x Hydrolases, Antibody Characterization and Analysis, Antibody Glycan Analysis, Application Index, |
| type | Type X |
| form | lyophilized powder |
| storage temp. | −20°C |
| Gene Information | Clostridium perfringens str. 13 ... nanJ(988807) |
Description
General description
Neuraminidase enzymes are glycoside hydrolase enzymes that catalyze hydrolysis of terminal sialic acid residues. The most well-known are the viral nearamidases, which promote influenza virus release. 3
Preparation Note
Purified by affinity chromatography from Type VIII (N 5631)
Unit Definition
One unit will liberate 1.0 μmole of N-acetylneuraminic acid per min at pH 5.0 at 37 °C using NAN-lactose or bovine submaxillary mucin unless otherwise specified.
Application
Neuraminidase from Clostridium perfringens has been used in a study to assess purification via affinity chromatography. 1 It has also been used in a study to investigate site-directed mutations of amino acids of the neuraminidase gene, nanH. 2
Biochem/physiol Actions
Hydrolyzes α(2→3), α(2→6), and α(2→8)-glycosidic linkages of terminal sialic residues of various glycomolecules.
Neuraminidase can block attachment of type 3 reovirus to cell membranes. This effect is related to the ability of neuraminidase to hydrolysis sialic acid residues within cell surface receptors.
Price and Availability
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