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  • N216 - Monoclonal Anti-Na+/Ca2+ Exchanger antibody produced in mouse

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N216 Sigma

Monoclonal Anti-Na+/Ca2+ Exchanger antibody produced in mouse

clone C2C12, ascites fluid

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cell Biology, Antibodies to Calcium Channels, Antibodies to Ion Channels,
species reactivity   rat, human, guinea pig, canine, rabbit
application(s)   immunohistochemistry (frozen sections): 1:200
  immunoprecipitation: suitable
  western blot: 1:1,000
clone   C2C12, monoclonal
antibody form   ascites fluid
isotype   IgM
mol wt   antigen mol wt 120 kDa (mature exchanger)
  antigen mol wt 160 kDa (non-reduced)
  antigen mol wt 70 kDa (proteolytic fragment)
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... SLC8A1(6546)
biological source   mouse
conjugate   unconjugated

Description

Immunogen

dog cardiac Na+/Ca2+ exchanger. The epitope is in the region of amino acids 371-525, which is on the intracellular side of the plasma membrane.

General description

Na+/Ca2+ exchanger is also known as solute carrier family 8 member A1 (SLC8A1) and is present in the plasma membrane. It is predicted to have nine transmembrane segments and the gene encoding SLC8A1 has three promoters.

Physical form

Solution in phosphate buffered saline containing 0.05% sodium azide.

Specificity

The antibody reacts specifically with Na+/Ca2+ exchanger in kidney and cardiac tissues. By immunohistology, staining of the plasma membrane and intense staining of the cardiac T-tubular membrane is observed. The antibody is not recommended for immunoblotting of rat tissues.

Biochem/physiol Actions

Na+/Ca2+ exchanger (SLC8A1, solute carrier family 8 member A1) is involved in Ca2+ homeostasis. Depending on physiological conditions prevailing in the cell, it can either pump out Na+ or Ca2+.

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