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N2773 Sigma

Neurotransmitter Release

  •  ISBN-10 0-19-963766-0

  •  ISBN-13 978-0-19-963766-9

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publication info   H. Bellen, ed., Oxford University Press, 1999, 458 pp., soft cover
mfr. no.   Oxford University Press

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General description

This book emphasizes the rationale by which proteins are assigned specific functions rather than just providing facts about function. Chapters cover properties of the synapse, techniques used to elucidate aspects of release, approaches used to identify proteins involved in neurotransmitter release, aspects of synaptic transmission, proteins that transport neurotransmitters and role of phospholipids in the process. Other topics include approaches to unravel the function of proteins in vivo along with endocytosis and recycling.

Table of Contents

1. An introduction to the nerve terminal,
2. Techniques for elucidating the secretory process: from Ca2+ entry to exocytosis,
3. Nerve terminal membrane trafficking proteins: from discovery to function,
4. The role of phospholipids in neurosecretion,
5. Neurotransmitter transporters,
6. Toxins that affect neurotransmitter release,
7. Functional studies of presynaptic proteins at the squid giant synapse,
8. Studying mutants that affect neurotransmitter release in C. elegans,
9. Dissecting the molecular mechanisms of neurotransmitter release in Drosophila,
10. Genetic analysis of neurotransmitter release in mice and humans,
11. Synaptic vesicle endocytosis and recycling,
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