Synonym: Acyl-neuraminyl Hydrolase, Receptor-destroying enzyme, Sialidase
|Related Categories||3.2.x.x Glycosidases, 3.x.x.x Hydrolases, Application Index, Biochemicals and Reagents, Carbohydrate Hydrolysis,|
|activity||≥0.1 units/mg solid (using mucin)|
|≥0.5 units/mg solid (using NAN-lactose)|
|foreign activity||Protease and NAN-aldolase, present|
|shipped in||dry ice|
|Gene Information||Clostridium perfringens str. 13 ... nanJ(988807)|
Neuraminidase enzymes are hydrolase enzymes that promote influenza virus release from infected cells and facilitate virus spread.
Prices based on units using NAN-lactose as substrate.
Prepared by salt fractionation.
One unit will liberate 1.0 μmole of N-acetylneuraminic acid per min at pH 5.0 at 37 °C using NAN-lactose or bovine submaxillary mucin unless otherwise specified.
Neuraminidase from Clostridium perfringens has been used in a study to assess binding with human T lymphocytes in sheep pretreated with neuraminidase. 1 It has also been used in a study to investigate the effect of bile salts on the action of hydrolysis by neuraminidase. 2
Hydrolyzes α(2→3), α(2→6), and α(2→8)-glycosidic linkages of terminal sialic residues of various glycomolecules.
Neuraminidase can increase aggregation in certain cell lines by removing exposed negatively charged sialic acid residues on the cell surface.
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recombinant, expressed in E. coli, buffered aqueous solution, ≥250 units/mg protein
Proteomics Grade, suitable for MALDI-TOF MS
Type VI, lyophilized powder, 6-10 units/mg protein (using NAN-lactose), 2-5 units/mg protein (mucin)
Type VIII, lyophilized powder, 10-20 units/mg protein (using NAN-lactose), 3.5-8.0 units/mg protein (mucin)
Type X, lyophilized powder, ≥50 units/mg protein (using NAN-lactose)
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Certificate of Origin
2.1. This procedure applies to products that have a specification for neuraminidase content by enzymatic determination.
From our library of Related Content, Sigma-Aldrich presents Enzyme Explorer: the most comprehensive source of enzymes, substrates, activators, & inhibitors.
Keywords: Cell culture, Cell disruption, Cell signaling, Diagnostic, Digestions, Drug discovery, Functional genomics, Gene expression, Genomics, Metabolic Pathways, Molecular biology, Neuroscience, Proteomics
Human parainfluenza virus infection of the airway epithelium: viral hemagglutinin-neuraminidase regulates fusion protein activation and modulates infectivity. Palermo, L.M., et al. J. Virol. 83, 6900-8, (2009)
Calyceramides A-C: neuraminidase inhibitory sulfated ceramides from the marine sponge Discodermia calyx. Nakao, Y., et al Tetrahedron 57, 3013-3017, (2001)
A study on the mechanism of intercellular adhesion. Effects of neuraminidase, calcium, and trypsin on the aggregation of suspended HeLa cells. Effects of Neuraminidase, Calcium, and Trypsin on the Aggregation of Suspended HeLa cells. Deman, J. J. Cell Biol. 60, 641-652., (1974)
Neuraminidase inhibitors for influenza: a review and public health perspective in the aftermath of the 2009 pandemic. Beck CR, Sokal R, Arunachalam N, et al. Influenza Other Respi. Viruses 7 Suppl 1, 14-24, (2013)
In situ molecular identification of the influenza A (H1N1) 2009 Neuraminidase in patients with severe and fatal infections during a pandemic in Mexico City. Ocadiz-Delgado R, Albino-Sanchez ME, Garcia-Villa E, et al. BMC Infect. Dis. 13, 20, (2013)
Pathway Pattern-based prediction of active drug components and gene targets from H1N1 influenza's treatment with maxingshigan-yinqiaosan formula. Dai W, Chen J, Lu P, et al. Mol. Biosyst. 9(3), 375-85, (2013)
NA proteins of influenza A viruses H1N1/2009, H5N1, and H9N2 show differential effects on infection initiation, virus release, and cell-cell fusion. Chen Q, Huang S, Chen J, et al. PLoS ONE 8(1), e54334, (2013)
What is the role of respiratory viruses in community-acquired pneumonia?: What is the best therapy for influenza and other viral causes of community-acquired pneumonia? Pavia AT Infect. Dis. Clin. North Am. 27(1), 157-75, (2013)
Identification of critical residues in the hemagglutinin and neuraminidase of influenza virus H1N1pdm for vaccine virus replication in embryonated chicken eggs. Wang W, Lu J, Cotter CR, et al. J. Virol. 87(8), 4642-9, (2013)
Polar residues and their positional context dictate the transmembrane domain interactions of influenza A neuraminidases. Nordholm J, da Silva DV, Damjanovic J, et al. J. Biol. Chem. 288(15), 10652-60, (2013)
Degradation, foraging, and depletion of mucus sialoglycans by the vagina-adapted Actinobacterium Gardnerella vaginalis. Lewis WG, Robinson LS, Gilbert NM, et al. J. Biol. Chem. 288(17), 12067-79, (2013)
Identification of selective inhibitors for human neuraminidase isoenzymes using C4,C7-modified 2-deoxy-2,3-didehydro-N-acetylneuraminic acid (DANA) analogues. Zhang Y, Albohy A, Zou Y, et al. J. Med. Chem. 56(7), 2948-58, (2013)
Trypanosoma cruzi trans-sialidase initiates a program independent of the transcription factors RORγt and Ahr that leads to IL-17 production by activated B cells. Bermejo DA, Jackson SW, Gorosito-Serran M, et al. Nat. Immunol. 14(5), 514-22, (2013)
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