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N3279 Sigma

Monoclonal Anti-Nerve Growth Factor-β antibody produced in mouse

clone 25623, purified immunoglobulin, lyophilized powder

Synonym: Anti-NGF-β

Description

Immunogen

recombinant human NGF-β.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.

Preparation Note

Purified using Protein G.

Biochem/physiol Actions

Nerve Growth factor (NGF) is a growth factor that is essential for the development and maintenance of the nervous system. NGF is composed of three non-covalently linked α, β and γ subunits. The β subunit is responsible for the biological functions of NGF. Nerve growth factor (NGF) binds to either to NGF receptor (NGFR) or the Trk receptor and can elicit biological responses through each of the receptors independently. NGF is important in the survival and differentiation of neurons and neural crest-derived cells during embryonic and early postnatal development and maintenance of peripheral neurons. NGF is also implicated in inflammation and allergic reactions.

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