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N3501 Sigma

β-Nicotinamide mononucleotide

95-100% (HPLC)

Synonym: β-NMN, β-Nicotinamide ribose monophosphate, NMN, Nicotinamide ribotide, Nicotinamide-1-ium-1-β-D-ribofuranoside 5′-phosphate

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Properties

Related Categories Biochemicals and Reagents, Cofactors, Enzymes, Inhibitors, and Substrates, Oxidation-Reduction
assay   95-100% (HPLC)
  95-100% (spectrophotometric assay)
storage temp.   −20°C

Description

Other Notes

Note: This is the common form of NMN. Do not confuse it with α-NMN.

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. N3501.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

Application

β-Nicotinamide mononucleotide (NMN) is used to study binding motifs within RNA aptamers and ribozyme activation processes involving β-nicotinamide mononucleotide (β-NMN)-activated RNA fragments.

Price and Availability

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Safety & Documentation

Safety Information

WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Peer-Reviewed Papers

References

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RNA aptamers that bind flavin and nicotinamide redox cofactors. Lauhon CT, Szostak JW. J. Am. Chem. Soc. 117, 1246-1257, (1995)

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Tailoring RNA modular units on a common scaffold: a modular ribozyme with a catalytic unit for β-nicotinamide mononucleotide-activated RNA ligation. Fujita Y, Furuta H, Ikawa Y. RNA 15, 877-888, (2009)

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Evolutionary optimization of a modular ligase ribozyme: a small catalytic unit and a hairpin motif masking an element that could form an inactive structure. Fujita Y, Furuta H, Ikawa Y. Nucleic Acids Res. 38, 3328-3339, (2010)

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Effect of nicotinamide mononucleotide on insulin secretion and gene expressions of PDX-1 and FoxO1 in RIN-m5f cells. Sheng F, Ren X, Dai X, et al. Zhong Nan Da Xue Xue Bao. Yi Xue Ban 36(10), 958-63, (2011)

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Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice. Yoshino J, Mills KF, Yoon MJ, et al. Cell Metab. 14(4), 528-36, (2011)

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Renal tubular Sirt1 attenuates diabetic albuminuria by epigenetically suppressing Claudin-1 overexpression in podocytes. Hasegawa K, Wakino S, Simic P, et al. Nat. Med. 19(11), 1496-504, (2013)

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A possibility of nutriceuticals as an anti-aging intervention: activation of sirtuins by promoting mammalian NAD biosynthesis. Imai S Pharmacol. Res. 62(1), 42-7, (2010)

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The high-resolution crystal structure of periplasmic Haemophilus influenzae NAD nucleotidase reveals a novel enzymatic function of human CD73 related to NAD metabolism. Garavaglia S, Bruzzone S, Cassani C, et al. Biochem. J. 441(1), 131-41, (2012)

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Nicotinamide phosphoribosyltransferase/visfatin does not catalyze nicotinamide mononucleotide formation in blood plasma. Hara N, Yamada K, Shibata T, et al. PLoS ONE 6(8), e22781, (2011)

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Detection and pharmacological modulation of nicotinamide mononucleotide (NMN) in vitro and in vivo. Formentini L, Moroni F, and Chiarugi A Biochem. Pharmacol. 77(10), 1612-20, (2009)

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Effects of long-acting somatostatin analogues on adrenal growth and phosphoribosyl pyrophosphate formation in experimental diabetes. Kunjara S, Greenbaum AL, Sochor M, et al. Int. J. Exp. Pathol. 93(1), 56-69, (2012)

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Enzymatic biofuel cells utilizing a biomimetic cofactor. Campbell E, Meredith M, Minteer SD, et al. Chem. Commun. (Camb.) 48(13), 1898-900, (2012)

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CD73 protein as a source of extracellular precursors for sustained NAD+ biosynthesis in FK866-treated tumor cells. Grozio A, Sociali G, Sturla L, et al. J. Biol. Chem. 288(36), 25938-49, (2013)

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ArsAB, a novel enzyme from Sporomusa ovata activates phenolic bases for adenosylcobamide biosynthesis. Chan CH and Escalante-Semerena JC Mol. Microbiol. 81(4), 952-67, (2011)

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Identification of Isn1 and Sdt1 as glucose- and vitamin-regulated nicotinamide mononucleotide and nicotinic acid mononucleotide [corrected] 5'-nucleotidases responsible for production of nicotinamide riboside and nicotinic acid riboside. Bogan KL, Evans C, Belenky P, et al. J. Biol. Chem. 284(50), 34861-9, (2009)

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Dissecting cobamide diversity through structural and functional analyses of the base-activating CobT enzyme of Salmonella enterica. Chan CH, Newmister SA, Talyor K, et al. Biochim. Biophys. Acta 1840(1), 464-75, (2014)

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Induced fit and the catalytic mechanism of isocitrate dehydrogenase. Gonçalves S, Miller SP, Carrondo MA, et al. Biochemistry 51(36), 7098-115, (2012)

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Wld(S) reduces paraquat-induced cytotoxicity via SIRT1 in non-neuronal cells by attenuating the depletion of NAD. Qiujing Yu et al PLoS ONE 6, e21770, (2011)

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Comparative genomics of NAD(P) biosynthesis and novel antibiotic drug targets. Bi J, Wang H, and Xie J J. Cell Physiol. 226(2), 331-40, (2011)

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Mitochondria-localized NAD biosynthesis by nicotinamide mononucleotide adenylyltransferase in Jerusalem artichoke (Helianthus tuberosus L.) heterotrophic tissues. Di Martino C and Pallotta ML Planta 234(4), 657-70, (2011)

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A fluorometric assay for high-throughput screening targeting nicotinamide phosphoribosyltransferase. Zhang RY, Qin Y, Lv XQ, et al. Anal. Biochem. 412(1), 18-25, (2011)

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NAMPT/PBEF1 enzymatic activity is indispensable for myeloma cell growth and osteoclast activity. Venkateshaiah SU, Khan S, Ling W, et al. Exp. Hematol. 41(6), 547-557.e2, (2013)

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Recognition of nucleoside monophosphate substrates by Haemophilus influenzae class C acid phosphatase. Singh H, Schuermann JP, Reilly TJ, et al. J. Mol. Biol. 404(4), 639-49, (2010)

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Catalysis-based inhibitors of the calcium signaling function of CD38. Kwong AK, Chen Z, Zhang H, et al. Biochemistry 51(1), 555-64, (2012)

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Functional analysis of the nicotinate mononucleotide:5,6-dimethylbenzimidazole phosphoribosyltransferase (CobT) enzyme, involved in the late steps of coenzyme B12 biosynthesis in Salmonella enterica. Claas KR, Parrish JR, Maggio-Hall LA, et al. J. Bacteriol. 192(1), 145-54, (2010)

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Investigation of NADH binding, hydride transfer, and NAD(+) dissociation during NADH oxidation by mitochondrial complex I using modified nicotinamide nucleotides. Birrell JA and Hirst J Biochemistry 52(23), 4048-55, (2013)

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Identification of Mitochondrial Electron Transport Chain-Mediated NADH Radical Formation by EPR Spin-Trapping Techniques Matsuzaki, S., et al Biochemistry 50(50), 10792-10803, (2011)

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Visualization and quantification of NAD(H) in brain sections by a novel histo-enzymatic nitrotetrazolium blue staining technique. Balan IS, Fiskum G, and Kristian T Brain Res. 1316, 112-9, (2010)

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Crystallization and preliminary X-ray crystallographic analysis of quinolinate phosphoribosyltransferase from porcine kidney in complex with nicotinate mononucleotide. Youn HS, Kim MK, Kang GB, et al. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 68(Pt 12), 1488-90, (2012)

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Nicotinamide mononucleotide protects against pro-inflammatory cytokine-mediated impairment of mouse islet function. Caton PW, Kieswich J, Yaqoob MM, et al. Diabetologia 54(12), 3083-92, (2011)

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Characterization of human nicotinate phosphoribosyltransferase: Kinetic studies, structure prediction and functional analysis by site-directed mutagenesis. Galassi L, Di Stefano M, Brunetti L, et al Biochimie 94(2), 300-9, (2012)

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