Nystatin
≥4,400 USP units/mg
DOWNLOAD MSDS (PDF)Synonym: Fungicidin, Mycostatin
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CAS Number 1400-61-9
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EC Number 215-749-0
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PubChem Substance ID 24897647
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Popular Documents: Product Information Sheet (PDF) | Specification Sheet (PDF)
Properties
| Related Categories | Antibiotics, Antibiotics A to Z, Antibiotics N-S, Antifungal, Chemical Structure Class, |
| Quality Level | PREMIUM |
| storage temp. | −20°C |
Description
Biochem/physiol Actions
Mode of Action: Increases the permeability of the cell membrane of sensitive fungi by binding to sterols.
Antimicrobial spectrum: Yeasts and molds.
Nystatin binds to ergosterol in fungal cell membranes which causes the formation of pores in the membrane. Potassium and other cellular constituents leak from the pores causing cell death. Antimicrobial spectrum: Yeasts and molds.
Application
Product N3503 is ≥4,400 USP units/mg. Nystatin is a polyene, antifungal antibiotic with potent proinflammatory properties. It has many applications such as preventing cell culture contamination and inducing interleukin (IL)-, IL-8, and tumor necrosis factor α s secretion in TLR2-expressing THP1 cells 1. It is used as a fungal membrane (ergosterol binding) pore forming agent and to create nystatin/ergosterol based ion channels in lipid bilayers.
Protocols & Applications
Price and Availability
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250 μg/mL in deionized water, sterile-filtered, BioReagent, suitable for cell culture
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