|Related Categories||Antibiotics, Antibiotics A to Z, Antibiotics N-S, Antifungal, Biochemicals and Reagents,|
Mode of Action: Increases the permeability of the cell membrane of sensitive fungi by binding to sterols.
Antimicrobial spectrum: Yeasts and molds.
Nystatin binds to ergosterol in fungal cell membranes which causes the formation of pores in the membrane. Potassium and other cellular constituents leak from the pores causing cell death. Antimicrobial spectrum: Yeasts and molds.
Product N3503 is ≥4,400 USP units/mg. Nystatin is a polyene, antifungal antibiotic with potent proinflammatory properties. It has many applications such as preventing cell culture contamination and inducing interleukin (IL)-, IL-8, and tumor necrosis factor α s secretion in TLR2-expressing THP1 cells 1. It is used as a fungal membrane (ergosterol binding) pore forming agent and to create nystatin/ergosterol based ion channels in lipid bilayers.
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1. Nystatin Induces Secretion of Interleukin (IL)-1β, IL-8, and Tumor Necrosis Factor α by a Toll-LikeReceptor-Dependent Mechanism. Raymund R. Razonable, Martin Henault, et al. Antimicrob. Agents Chemother. 49, 3546-3549, (2005)
Lectin-like oxidized LDL receptor-1 is palmitoylated and internalizes ligands via caveolae/raft-dependent endocytosis. Kumano-Kuramochi M, Xie Q, Kajiwara S, et al. Biochem. Biophys. Res. Commun. 434(3), 594-9, (2013)
The interaction of polysaccharide from Auricularia polytricha with quantum dots and the protection of plasmid DNA from damage. Wang W, Zhang G, and Zou J Appl. Biochem. Biotechnol. 169(8), 2263-72, (2013)
Prospective trial finds nystatin mouthwash effective prophylaxis for pulmonary invasive fungal infections that originate in the throat of patients with hematologic malignancies. Hu R, Jiang X, and Wu Y Neoplasma 60(3), 315-21, (2013)
Effect of selective decontamination on antimicrobial resistance in intensive care units: a systematic review and meta-analysis. Daneman N, Sarwar S, Fowler RA, et al. Lancet Infect. Dis. 13(4), 328-41, (2013)
Peel bond strength of resilient liner modified by the addition of antimicrobial agents to denture base acrylic resin. Alcântara CS, Macêdo AF, Gurgel BC, et al. J. Appl. Oral Sci. 20(6), 607-12, (2012)
[Clinical factors associated with invasive pulmonary aspergillosis in patients with chronic pneumopathies and respiratory isolation of Aspergillus spp]. Castón JJ, Linares MJ, Rivero A, et al. Med. Clin. (Barc.) 139(15), 668-71, (2012)
Chitosan and gelatin based prototype delivery systems for the treatment of oral mucositis: from material to performance in vitro. Perchyonok VT, Zhang S, and Oberholzer T Curr. Drug Deliv. 10(1), 144-50, (2013)
Chemoprophylaxis of neonatal fungal infections in very low birthweight infants: efficacy and safety of fluconazole and nystatin. Blyth CC, Barzi F, Hale K, et al. J. Paediatr. Child Health 48(9), 846-51, (2012)
Prophylactic oral/topical non-absorbed antifungal agents to prevent invasive fungal infection in very low birth weight infants. Austin N, Darlow BA, and McGuire W Cochrane Database Syst. Rev. 3, CD003478, (2013)
Candidemia in Neurosurgical Intensive Care Unit: preliminary analysis of the effect of topical Nystatin prophylaxis and adequate source control on patients with early tracheostomy intubation. Giuliano S, Ceccarelli G, Renzini V, et al. Ann. Ig. 25(1), 57-64, (2013)
Free radical scavenging capacity, anticandicidal effect of bioactive compounds from Sida cordifolia L., in combination with nystatin and clotrimazole and their effect on specific immune response in rats. Ouédraogo M, Konaté K, Lepengué AN, et al. Ann. Clin. Microbiol. Antimicrob. 11, 33, (2012)
In vitro antifungal activity of two tissue conditioners combined with nystatin, miconazole and fluconazole against Candida albicans. Chopde N, Pharande A, Khade MN, et al. J. Contemp. Dent. Pract. 13(5), 695-8, (2012)
Comparison of denture microwave disinfection and conventional antifungal therapy in the treatment of denture stomatitis: a randomized clinical study. Silva MM, Mima EG, Colombo AL, et al. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. 114(4), 469-79, (2012)
Investigation of folate-conjugated fluorescent silica nanoparticles for targeting delivery to folate receptor-positive tumors and their internalization mechanism. Yang H, Lou C, Xu M, et al. Int. J. Nanomedicine 6, 2023-32, (2011)
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