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N3510 Sigma

Niclosamide

Synonym: 2′,5-Dichloro-4′-nitrosalicylanilide

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Properties

Related Categories Antibiotics, Antibiotics A to Z, Antibiotics N-S, Antiparasitic / Antiprotozoal / Anthelminthic, Autophagy,
InChI Key   RJMUSRYZPJIFPJ-UHFFFAOYSA-N
solubility   acetone: methanol: soluble50 mg/mL (methanol:acetone (1:1))
Mode of action   enzyme | inhibits
antibiotic activity spectrum   parasites

Description

Application

Niclosamide is a teniacide in the anthelmintic family. It is effective against cestodes that infect humans. Niclosamide is used to study the Wnt/Frizzled-1 signaling pathway. It is used to inhibit transcription and DNA binding of the NF-?B pathway and it increases ROS levels to induce apoptosis in acute myelogenous leukemia (AML) cells.

Biochem/physiol Actions

Niclosamide uncouples oxidative phosphorylation in the tapeworm and inhibits mitochondrial oxidative phosphorylation of parasitic helminths. It blocks tumor necrosis factor-induced IκBα phosphorylation, translocation of p65, and expression of NF-κΒ– regulated genes in AML cells.

Price and Availability


All labs need water
Safety & Documentation

Safety Information

Symbol 
GHS09  GHS09
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
2
RTECS 
VN8400000
Protocols & Articles
Peer-Reviewed Papers
15

References

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