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N3877 Sigma

Potassium 4-nitrophenyl sulfate

sulfatase substrate

Synonym: 4-Nitrophenyl sulfate potassium salt



Related Categories Activity, Biochemicals and Reagents, Chromogenic, Enzyme Substrates, Enzymes, Inhibitors, and Substrates More...
mp   246-250 °C(lit.)
storage temp.   −20°C



Chromogenic sulfatase substrate.

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Safety Information

WGK Germany 

Protocols & Articles

Peer-Reviewed Papers


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Gas chromatographic-mass spectrometric analysis for measurement of p-cresol and its conjugated metabolites in uremic and normal serum. de Loor H, Bammens B, Evenepoel P, et al. Clin. Chem. 51(8), 1535-8, (2005)


Theoretical comparison of p-nitrophenyl phosphate and sulfate hydrolysis in aqueous solution: implications for enzyme-catalyzed sulfuryl transfer. Kamerlin SC J. Org. Chem. 76(22), 9228-38, (2011)


Effect of hyperglycemia on the intestinal elimination of p-nitrophenol in the rat. Fischer E, Rafiei A, and Bojcsev S Acta Physiol. Hung. 84(3), 287-8, (1996)


Simple methanesulfonates are hydrolyzed by the sulfatase carbonic anhydrase activity. Kazancioğlu EA, Güney M, Şentürk M, et al. J. Enzyme Inhib. Med. Chem. 27(6), 880-5, (2012)


Desulfation of 3,5,3'-triiodothyronine sulfate by microsomes from human and rat tissues. Kung MP, Spaulding SW, and Roth JA Endocrinology 122(4), 1195-200, (1988)


Isotope effects and medium effects on sulfuryl transfer reactions. Hoff RH, Larsen P, and Hengge AC J. Am. Chem. Soc. 123(38), 9338-44, (2001)


High-performance liquid chromatographic analysis of p-nitrophenol and its conjugates in biological samples. Morris ME and Hansel SB J. Chromatogr. A 532(2), 285-93, (1990)


Biotransformation of the organophosphorus insecticides parathion and methyl parathion in male and female rat livers perfused in situ. Zhang HX and Sultatos LG Drug Metab. Dispos. 19(2), 473-7, (1991)


Arylsulfatase activity of Mycobacterium avium, M. intracellulare, and M. scrofulaceum. Falkinham JO Int. J. Syst. Bacteriol. 40(1), 66-70, (1990)


MRP isoforms and BCRP mediate sulfate conjugate efflux out of BeWo cells. Mitra P and Audus KL Int. J. Pharm. 384(1-2), 15-23, (2010)


Efficient cleavage of conjugates of drugs or poisons by immobilized beta-glucuronidase and arylsulfatase in columns. Toennes SW and Maurer HH Clin. Chem. 45(12), 2173-82, (1999)


Hepatic uptake of p-nitrophenyl sulfate by transporter that acetaminophen sulfate shares for uptake: sulfate moiety as a vector for metabolite transport. Sakuma-Sawada N, Iida S, Mizuma T, et al. Res. Commun. Mol. Pathol. Pharmacol. 97(2), 131-8, (1997)


Purification and characterization of arylsulfatase from Sphingomonas sp. AS6330. Kim JH, Byun DS, Godber JS, et al. Appl. Microbiol. Biotechnol. 63(5), 553-9, (2004)


Nucleotide binding and sulfation catalyzed by phenol sulfotransferase. Lin ES and Yang YS Biochem. Biophys. Res. Commun. 271(3), 818-22, (2000)


A continuous assay for the spectrophotometric analysis of sulfotransferases using aryl sulfotransferase IV. Burkart MD and Wong CH Anal. Biochem. 274(1), 131-7, (1999)


Relationship between substrate activity and pKa value of phenols on sulfotransferase from Eubacterium A-44. Konishi-Imamura L, Kim DH, and Kobashi K Biochem. Int. 28(4), 725-34, (1992)


Regulation of arylsulfate sulfotransferase from a human intestinal bacterium by nucleotides and magnesium ion. Konishi-Imamura L, Kim DH, Koizumi M, et al. J. Enzym. Inhib. 8(4), 233-41, (1995)


Sulfating-activity and stability of cDNA-expressed allozymes of human phenol sulfotransferase, ST1A3*1 ((213)Arg) and ST1A3*2 ((213)His), both of which exist in Japanese as well as Caucasians. Ozawa S, Shimizu M, Katoh T, et al. J. Biochem. 126(2), 271-7, (1999)


Kinetic studies on a novel sulfotransferase from Eubacterium A-44, a human intestinal bacterium. Kim DH and Kobashi K J. Biochem. 109(1), 45-8, (1991)


para-Nitrophenyl sulfate activation of human sulfotransferase 1A1 is consistent with intercepting the E[middle dot]PAP complex and reformation of E[middle dot]PAPS. Tyapochkin E, Cook PF, and Chen G J. Biol. Chem. 284(43), 29357-64, (2009)


Natural killer cell cytolytic granule-associated enzymes. I. Purification, characterization, and analysis of function of an enzyme with sulfatase activity. Amoscato AA, Brumfield AM, Sansoni SB, et al. J. Immunol. 147(3), 950-8, (1991)


Reaction product affinity regulates activation of human sulfotransferase 1A1 PAP sulfation. Tyapochkin E, Kumar VP, et al. Arch. Biochem. Biophys. 506, 137-141, (2011)


Dermal metabolism of 4-nitrophenol and 4-nitroanisole in single-pass perfused rabbit ears. Henrikus BM, Breuer W, and Kampffmeyer HG Xenobiotica 21(10), 1229-41, (1991)


Inhibition of the hepatic uptake of paracetamol sulphate by anionic compounds. Sakuma-Sawada N, Iida S, Mizuma T, et al. J. Pharm. Pharmacol. 49(8), 743-6, (1997)


Potassium p-nitrophenyl sulfate. Sierosławski K, Popek T, and Lis T Acta Crystallogr. C 60(Pt 7), m327-9, (2004)


Beil. 6,II,225

FT-IR 1 (2), 502:D / FT-IR 2 (2), 2271:A / FT-NMR 1 (2), 697:B / IR-Spectra (2), 1010:G / IR-Spectra (3), 1161:A / NMR-Reference 2 (2), 824:A / RegBook 1 (1), 1559:L / Sigma FT-IR 1 (1), 534:B / Structure Index 1, 243:E:2

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