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  • N3908 - Anti-Nerve Growth Factor Receptor (NGFR p75) antibody produced in rabbit

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N3908 Sigma

Anti-Nerve Growth Factor Receptor (NGFR p75) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies against Proteins/Bioactives/Markers/Receptors for Stem Cell Biology, Antibodies for Apoptosis, Antibodies for Cell Biology,
species reactivity   rat
application(s)   immunohistochemistry (frozen sections): 1:10,000 using rat brain
  indirect immunofluorescence: 1:500 using NGF-treated PC12 cells
  microarray: suitable
  western blot: 1:5,000 using whole cell extract of NGF-treated PC12 cells
clone   polyclonal
antibody form   affinity isolated antibody
form   buffered aqueous solution
shipped in   dry ice
storage temp.   −20°C
Gene Information   rat ... Ngfr(24596)
biological source   rabbit
conjugate   unconjugated

Description

Immunogen

synthetic peptide corresponding to the C-terminal of NGFR p75 of rat origin (amino acids 407-425 with N-terminally added lysine) conjugated to KLH.

General description

Peptide sequence of the antigen is highly conserved in human (single amino acid substitution) and chicken NGFR p75.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide.

Biochem/physiol Actions

Neurotrophins (NT) are growth factors that are essential for the development and maintenance of the nervous system. One of the receptors that mediate the effects of NTs is the Nerve Growth Factor Receptor/TNFRSF16 (p75NGFR, p75NTR). NGFR mediates the effects of NGF that are important in the survival and differentiation of neurons and neural crest-derived cells, during embryonic and early postnatal development. Expression of NGFR has been associated with favorable prognosis and survival in breast and pancreatic cancers.

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