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N4766 Sigma

N-Nitroso-N-methylurea

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Synonym: MNU, N-Methyl-N-nitrosourea

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Properties

Related Categories Cancer Research, Carcinogens, Cell Biology More...
contains   aqueous acetic acid as stabilizer
storage temp.   2-8°C

Description

Biochem/physiol Actions

DNA alkylating agent that is carcinogenic in many animal species. Although it can induce benign and malignant tumors in most organs, MNU is most often used to model mammary tumor initiation and progression.

Packaging

25, 100 g in glass bottle

Weight on dry basis.

Price and Availability


All labs need water
Safety & Documentation

Safety Information

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Articles

Carcinogenesis and Epigenetics

Cancer research has revealed that the classical model of carcinogenesis, a three step process consisting of initiation, promotion, and progression, is not complete. The expansion of the carcinogenesi...
Vicki Caligur
BioFiles 2008, 3.5, 18.
Keywords: Acetylations, Adhesion, Alkylations, Apoptosis, Biofiles, Cancer, Carcinogens, Cell division, Cell proliferation, Cell signaling, DNA microarrays, Drug discovery, Environmental, Epigenetics, Events, Gene expression, Genetic, Hormones, Metabolism, Methylations, Microarray Analysis, Mutagens, PAGE, Recombination, Reductions, Sequences, Transcription, Type, transformation

DNA Damage and Repair

Damage to cellular DNA is involved in mutagenesis and the development of cancer. The DNA in a human cell undergoes several thousand to a million damaging events per day, generated by both external (e...
Keywords: AGE, Alkylations, Apoptosis, Biochemistry, Cancer, Carcinogens, Catalysis, Clinical, DNA replication, Deaminations, Degradations, Eliminations, Environmental, Enzymology, Gene expression, Genetic, Infrared spectroscopy, Metabolites, Methylations, Mutagens, Oncology, Oxidations, Polymorphisms, Rearrangements, Recombination, Substitutions, Transcription, transformation

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Peer-Reviewed Papers
15

References

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08168 Timestrip Plus 8 °C

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