|Related Categories||Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Chloride Channel Modulators, Ion Channels,|
|solubility||ethanol: soluble3 mg/mL|
|DMSO: soluble37 mg/mL|
Potent chloride channel blocker.
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. N4779.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.
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≥80% (elemental analysis), powder
≥98% (HPLC), powder
≥98% (HPLC), solid
From a functional viewpoint, several different types of chloride channels showing different electrophysiological and regulatory characteristics have been described. These can be loosely grouped into ...
Keywords: Anti-depressants, Cancer, Gene expression, Hormones, Ligands, Neurotransmitters, Phosphorylations
Relaxation of endothelin-1-induced pulmonary arterial constriction by niflumic acid and NPPB: mechanism(s) independent of chloride channel block. Kato, K., et al. J. Pharmacol. Exp. Ther. 288, 1242, (1999)
Bestrophin-encoded Ca²⁺-activated Cl⁻ channels underlie a current with properties similar to the native current in the moth Spodoptera littoralis olfactory receptor neurons. François A, Grauso M, Demondion E, et al. PLoS ONE 7(12), e52691, (2012)
The glucokinase activator GKA50 causes an increase in cell volume and activation of volume-regulated anion channels in rat pancreatic β-cells. McGlasson L, Best L, and Brown PD Mol. Cell. Endocrinol. 342(1-2), 48-53, (2011)
The significance of chloride in the inhibitory action of disodium cromoglycate on immunologically-stimulated rat peritoneal mast cells. Law JK, Yeung CK, Wan SP, et al. Biochim. Biophys. Acta 1810(9), 867-74, (2011)
Parathyroid hormone (PTH) rapidly enhances CFTR-mediated HCO₃⁻ secretion in intestinal epithelium-like Caco-2 monolayer: a novel ion regulatory action of PTH. Laohapitakworn S, Thongbunchoo J, Nakkrasae LI, et al. Am. J. Physiol. Cell Physiol. 301(1), C137-49, (2011)
CFTR is restricted to a small population of high expresser cells that provide a forskolin-sensitive transepithelial Cl- conductance in the proximal colon of the possum, Trichosurus vulpecula. Fan S, Harfoot N, Bartolo RC, et al. J. Exp. Biol. 215(Pt 7), 1218-30, (2012)
Peripheral antinociception induced by δ-opioid receptors activation, but not μ- or κ-, is mediated by Ca²⁺-activated Cl⁻ channels. Pacheco Dda F, Pacheco CM, and Duarte ID Eur. J. Pharmacol. 674(2-3), 255-9, (2012)
ClC-3 is a main component of background chloride channels activated under isotonic conditions by autocrine ATP in nasopharyngeal carcinoma cells. Yang L, Ye D, Ye W, et al. J. Cell Physiol. 226(10), 2516-26, (2011)
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