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N5017 Sigma

Neuropeptide Y human

≥95% (HPLC), powder, synthetic

Synonym: NPY, hNPY

  • CAS Number 90880-35-6

  • Empirical Formula (Hill Notation) C189H285N55O57S

  • Molecular Weight 4271.68

  •  MDL number MFCD00212432

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Gastrointestinal Peptides, Neuropeptide Y, Neuropeptide Y and Peptide YY,
biological source   synthetic
assay   ≥95% (HPLC)
form   powder
color   white
solubility   H2O: 1 mg/mL
storage temp.   −20°C
Gene Information   human ... NPY(4852)

Description

Amino Acid Sequence

Tyr-Pro-Ser-Lys-Pro-Asp-Asn-Pro-Gly-Glu-Asp-Ala-Pro-Ala-Glu-Asp-Met-Ala-Arg-Tyr-Tyr-Ser-Ala-Leu-Arg-His-Tyr-Ile-Asn-Leu-Ile-Thr-Arg-Gln-Arg-Tyr-NH2

Other Notes

Lyophilized from 0.1% TFA in H2O

Application

Neuropeptide Y (NPY) human has been used:
• to study the effect of antiepileptic effects on pentylenetetrazole (PTZ) rats.
• as a standard in high-performance liquid chromatography (HPLC) standard and control to verify specificity of the antibodies.
• to study the effect of NPY on motor and electroencephalographic (EEG) seizures induced by kainic acid.

Biochem/physiol Actions

Neuropeptide Y (NPY) plays a vital role in various processes including feeding behaviour, anxiety, epilepsy, circadian, as well as rhythm memory processing, sleep, pain and drug addiction. In addition, it is also implicated in regulation of appetite, body weight and obesity. It controls central endocrine secretion and has potent vasoactive effects on the cardiovascular system. NPY is involved in the pathogenesis of atherosclerosis and coronary artery disease. NPY exhibits antimicrobial activity against Cryptococcus neoformans, Candida albicans and Arthroderma simii.

Vasoconstrictor; brain peptide that inhibits Ca2+-activated K+ channels in vascular smooth muscle. Implicated in the control of blood pressure, sexual behavior and food intake. Inhibits cholecystokinin- and secretin-stimulated pancreatic secretion.

General description

Neuropeptide Y is a regulatory molecule encoded by a gene mapped to human chromosome 7p15. Neuropeptide Y is a 36 amino acid protein with C-terminal α-amide structure. It is ubiquitously distributed in heart and brain, but at high levels in paraventricular hypothalamic nucleus, hypothalamic arcuate nucleus, suprachiasmatic nucleus, median eminence, dorsomedial, hypothalamic nucleus, paraventricular thalamic nuclei. NPY is a member of antimicrobial peptide family, which also include dermaseptins, cecropins or magainins.

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Amplified Detection

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Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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92210 Timestrip Plus 0 °C
06693 Timestrip Plus -20 °C

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