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N5135 Sigma

Normorphine hydrochloride monohydrate

  • CAS Number 3372-02-9

  • Empirical Formula (Hill Notation) C16H17NO3 · HCl · H2O

  • Molecular Weight 325.79

  •  EC Number 222-152-9

  • Popular Documents:  Datasheet (PDF)  

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Properties

drug control   USDEA Schedule I; Home Office Schedule 2; stupéfiant; kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada

Description

Biochem/physiol Actions

Narcotic analgesic

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Safety & Documentation

Safety Information

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GHS07  GHS07
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WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles

Peer-Reviewed Papers

References

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Affinity of normorphine for its pharmacologic receptor in the naive and morphine-tolerant guinea-pig isolated ileum. Porreca, et al. J. Pharmacol. Exp. Ther. 225, 688, (1983)

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Morphine pharmacokinetics and metabolism in humans. Enterohepatic cycling and relative contribution of metabolites to active opioid concentrations. Hasselström J and Säwe J Clin. Pharmacokinet. 24(4), 344-54, (1993)

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Characterization of acute homologous desensitization of mu-opioid receptor-induced currents in locus coeruleus neurones. Osborne PB and Williams JT Br. J. Pharmacol. 115(6), 925-32, (1995)

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Disposition and analgesic effects of systemic morphine, morphine-6-glucuronide and normorphine in rat. Hasselström J, Svensson JO, Säwe J, et al. Pharmacol. Toxicol. 79(1), 40-6, (1996)

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High-performance liquid chromatography-mass spectrometry-mass spectrometry analysis of morphine and morphine metabolites and its application to a pharmacokinetic study in male Sprague-Dawley rats. Zheng M, McErlane KM, and Ong MC J. Pharm. Biomed. Anal. 16(6), 971-80, (1998)

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High-performance liquid chromatographic monitoring of intravenously administered diacetylmorphine and morphine and their metabolites in human plasma. Bourquin D, Lehmann T, Hämmig R, et al. J. Chromatogr. B. Biomed. Sci. Appl. 694(1), 233-8, (1997)

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Identification of CYP3A4 and CYP2C8 as the major cytochrome P450 s responsible for morphine N-demethylation in human liver microsomes. Projean D, Morin PE, Tu TM, et al. Xenobiotica 33(8), 841-54, (2003)

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Opiate concentrations following the ingestion of poppy seed products--evidence for 'the poppy seed defence'. Meadway C, George S, and Braithwaite R Forensic Sci. Int. 96(1), 29-38, (1998)

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High-performance liquid chromatographic determination of morphine and its metabolites in plasma using diode-array detection. Wielbo D, Bhat R, Chari G, et al. J. Chromatogr. A 615(1), 164-8, (1993)

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Biochemical synthesis, purification and preliminary pharmacological evaluation of normorphine-3-glucuronide. Smith GD, Prankerd RJ, and Smith MT Life Sci. 61(2), 95-104, (1997)

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Different biotransformation of morphine in isolated liver cells from guinea pig and rat. Aasmundstad TA, Ripel A, Bodd E, et al. Biochem. Pharmacol. 46(6), 961-8, (1993)

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A rapid GC-MS method for the determination of dihydrocodeine, codeine, norcodeine, morphine, normorphine and 6-MAM in urine. Meadway C, George S, and Braithwaite R Forensic Sci. Int. 127(1-2), 136-41, (2002)

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An improved extraction method for the HPLC determination of morphine and its metabolites in plasma. Pawula M, Barrett DA, and Shaw PN J. Pharm. Biomed. Anal. 11(4-5), 401-6, (1993)

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Determination of multiple drugs of abuse in human urine using capillary electrophoresis with fluorescence detection. Alnajjar A, Butcher JA, and McCord B Electrophoresis 25(10-11), 1592-600, (2004)

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Cation-selective exhaustive injection and sweeping micellar electrokinetic chromatography for analysis of morphine and its four metabolites in human urine. Lin YH, Chiang JF, Lee MR, et al. Electrophoresis 29(11), 2340-7, (2008)

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The disposition of morphine and its metabolites in the in-situ rat isolated perfused liver. Evans AM and Shanahan K J. Pharm. Pharmacol. 47(4), 333-9, (1995)

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Analysis of unconjugated morphine, codeine, normorphine and morphine as glucuronides in small volumes of plasma from children. Watson DG, Su Q, Midgley JM, et al. J. Pharm. Biomed. Anal. 13(1), 27-32, (1995)

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Fatal and severe codeine intoxication in 3-year-old twins--interpretation of drug and metabolite concentrations. Ferreirós N, Dresen S, Hermanns-Clausen M, et al. Int. J. Legal Med. 123(5), 387-94, (2009)

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Ethanol interference with morphine metabolism in isolated guinea pig hepatocytes. Aasmundstad TA, Lillekjendlie B, and Mørland J Pharmacol. Toxicol. 79(3), 114-9, (1996)

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Serum and cerebrospinal fluid morphine pharmacokinetics after single doses of intravenous and intramuscular morphine after hip replacement surgery. Dale O, Thoner J, Nilsen T, et al. Eur. J. Clin. Pharmacol. 63(9), 837-42, (2007)

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Partial and full agonism in endomorphin derivatives: comparison by null and operational model. Rónai AZ, Al-Khrasani M, Benyhe S, et al. Peptides 27(6), 1507-13, (2006)

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A novel opioid structure which accepts protonated as well as non-protonated nitrogen: a family of pure, delta receptor selective antagonists. Rónai AZ, Botyánszki J, Hepp J, et al. Life Sci. 50(18), 1371-8, (1992)

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Evidence that cannabinoid-induced inhibition of electrically evoked contractions of the myenteric plexus--longitudinal muscle preparation of guinea-pig small intestine can be modulated by Ca2+ and cAMP. Coutts AA and Pertwee RG Can. J. Physiol. Pharmacol. 76(3), 340-6, (1998)

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Kinetic parameters of antagonism by the delta opioid receptor selective peptide antagonist Boc-Tyr-Pro-Gly-Phe-Leu-Thr against selective and non-selective agonists in the mouse vas deferens. Rónai AZ, Magyar A, and Medzihradszky K Neuropeptides 25(2), 127-9, (1993)

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Simultaneous quantification of opiates and effect of pigmentation on its deposition in hair. Lee S, Han E, Kim E, et al. Arch. Pharm. Res. 33(11), 1805-11, (2010)

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beta-Funaltrexamine, a gauge for the recognition site of wildtype and mutant H297Q mu-opioid receptors. Spivak CE, Beglan CL, Zöllner C, et al. Synapse 49(1), 55-60, (2003)

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