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N5148 Sigma

Nodularin

cyanotoxin

Synonym: 1,4,8,11,15-Pentaazacyclononadecane, cyclic peptide

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Properties

Related Categories Application Index, Biochemicals and Reagents, Cell Signaling Enzymes, Cyanobacterial Toxins, Enzymes, Inhibitors, and Substrates More...
InChI Key   IXBQSRWSVIBXNC-HSKGSTCASA-N
solubility   methanol: soluble2 mg/mL (Further dilute to 10% (v/v) methanol. Store solutions at −20°C for up to six months.)
storage temp.   2-8°C

Description

Biochem/physiol Actions

Potent inhibitor of protein phosphatases types 1 and 2A. Tumor promoter in experimental animal model.; at higher doses, causes massive liver hemorrhage. Tumor-promoting effect is due to increasing oxidative stress, as evidenced by reduced levels of glutathione and appearance of oxidative damage in DNA bases.

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Biomedical Applications
Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Precautionary statements 
RIDADR 
UN 2811PIH 6.1 / PGI
WGK Germany 
3
RTECS 
GU2294250

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Articles

Carcinogenesis and Epigenetics

Cancer research has revealed that the classical model of carcinogenesis, a three step process consisting of initiation, promotion, and progression, is not complete. The expansion of the carcinogenesi...
Vicki Caligur
BioFiles 2008, 3.5, 18.
Keywords: Acetylations, Adhesion, Alkylations, Apoptosis, Biofiles, Cancer, Carcinogens, Cell division, Cell proliferation, Cell signaling, DNA microarrays, Drug discovery, Environmental, Epigenetics, Events, Gene expression, Genetic, Hormones, Metabolism, Methylations, Microarray Analysis, Mutagens, PAGE, Recombination, Reductions, Sequences, Transcription, Type, transformation

Peer-Reviewed Papers
15

References

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