• USA Home
  • N5260 - (−)-Nicotine hydrogen tartrate salt

EMAIL THIS PAGE TO A FRIEND

N5260 Sigma

(−)-Nicotine hydrogen tartrate salt

≥98% (TLC), powder

Synonym: (−)-1-Methyl-2-(3-pyridyl)pyrrolidine (+)-bitartrate salt

Purchase

Properties

Related Categories Agonists, Alkaloid, Cell Biology, Cell Signaling and Neuroscience, Cholinergics,
assay   ≥98% (TLC)
form   powder
color   white to off-white
solubility   H2O: soluble50 mg/mL
Gene Information   human ... CHRNA1(1134), CHRNA10(57053), CHRNA2(1135), CHRNA3(1136), CHRNA4(1137), CHRNA5(1138), CHRNA6(8973), CHRNA7(1139), CHRNA9(55584), CHRNB1(1140), CHRNB2(1141), CHRNB3(1142), CHRNB4(1143)

Description

Biochem/physiol Actions

Prototype nicotinic acetylcholine receptor agonist; naturally occurring isomer.

Price and Availability

Customers Also Viewed

(±)-Nicotine

≥99% (TLC), liquid

(−)-Nicotine

PESTANAL®, analytical standard

≥95% (TLC), ~40 % (w/v) in H2O (based on free base)

European Pharmacopoeia (EP) Reference Standard

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
Hazard Codes (Europe) 
Risk Statements (Europe) 
Safety Statements (Europe) 
13-28-45-61
RIDADR 
UN 1659 6.1 / PGII
WGK Germany 
2
RTECS 
QT0350000

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Peer-Reviewed Papers

References

Set your institution to view full text papers.

Autoradiographic comparison of [3H](−)nicotine[3H]cytisine and [3H]epibatidine binding in relation to vesicular acetylcholine transport sites in the temporal cortex in Alzheimer's disease. Sihver, W., et al. Neuroscience 94, 685-696, (1999)

Loading...


The pharmacology of (−)-nicotine and novel cholinergic channel modulators. Brioni, J.D., et al. Adv. Pharmacol. 37, 153-214, (1997)

Loading...


Heteromeric complexes of α5 and/or α7 subunits. Effects of calcium and potential role in nicotine-induced presynaptic facilitation. Girod, R., et al. Ann. N. Y. Acad. Sci. 868, 578-590, (1999)

Loading...


Pathological mutations of nicotinic receptors and nicotine-based therapies for brain disorders. Lena, C., and Changeux, J.P. Curr. Opin. Neurobiol. 7, 674-682, (1997)

Loading...


Prenatal Nicotine-exposure Alters Fetal Autonomic Activity And Medullary Neurotransmitter Receptors: Implications For Sudden Infant Death Syndrome. Duncan, J.R., et al. J. Appl. Physiol. 107, 1579-90, (2009)

Loading...


Nicotine and sympathetic neurotransmission. Haass, M., and Kubler, W., Cardiovasc. Drugs Ther. 10, 657, (1997)

Loading...


Acetylcholine Induces Ca2+ Signaling In Chicken Retinal Pigmented Epithelial Cells During Dedifferentiation. Sekiguchi-Tonosaki, M., et al. Am. J. Physiol. Cell Physiol. 296, C1195-206, (2009)

Loading...


Varenicline ameliorates nicotine withdrawal-induced learning deficits in C57BL/6 mice. Raybuck JD Behav. Neurosci. 122(5), 1166-71, (2008)

Loading...


Nicotine withdrawal-induced deficits in trace fear conditioning in C57BL/6 mice--a role for high-affinity beta2 subunit-containing nicotinic acetylcholine receptors. Raybuck JD Eur. J. Neurosci. 29(2), 377-87, (2009)

Loading...


Acute nicotine reduces and repeated nicotine increases spontaneous activity in male and female Lewis rats. Prus AJ Pharmacol. Biochem. Behav. 91(1), 150-4, (2008)

Loading...


Decreases in brain reward function reflect nicotine- and methamphetamine-withdrawal aversion in rats. Hisatsugu Miyata et al Curr. Neuropharmacol. 9, 63-7, (2011)

Loading...


Merck 14,6524

Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?