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  • N5408 - Monoclonal Anti-Nerve Growth Factor Receptor (NGFR p75) antibody produced in mouse

N5408 Sigma

Monoclonal Anti-Nerve Growth Factor Receptor (NGFR p75) antibody produced in mouse

clone ME20.4, ascites fluid

Synonym: Anti-NGFR p75


Related Categories Alphabetical Index, Antibodies, Antibodies for Apoptosis, Antibodies for Cell Biology, Antibodies for Kinase/Phosphatase Biology,
species reactivity   human, racoon, monkey, pig, feline
does not react with   mouse, chicken, rat
application(s)   flow cytometry: suitable
  immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:1,000 using human tongue
  immunohistochemistry (frozen sections): suitable
  immunoprecipitation: suitable
  indirect ELISA: suitable
  microarray: suitable
  neutralization: suitable
  radioimmunoassay: suitable
  western blot: suitable
clone   ME20.4, monoclonal
antibody form   ascites fluid
isotype   IgG1
mol wt   antigen mol wt 75 kDa
contains   15 mM sodium azide
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... NGFR(4804)
biological source   mouse
conjugate   unconjugated



human melanoma cell line WM245.

General description

Recognizes the low affinity human NGFR p75 (also known as gp75NGFR , p75NGFR and p75NTR). The epitope recognized by the antibody exists within the third or fourth cysteine-rich repeats of the NGFR molecule. May be used in various immunoassays including inhibition of NGF binding to p75-NGFR and as a cholinergic immunotoxin.

Biochem/physiol Actions

Neurotrophins (NT) are growth factors that are essential for the development and maintenance of the nervous system. One of the receptors that mediate the effects of NTs is the Nerve Growth Factor Receptor/TNFRSF16 (p75NGFR, p75NTR). NGFR mediates the effects of NGF that are important in the survival and differentiation of neurons and neural crest-derived cells, during embryonic and early postnatal development. Expression of NGFR has been associated with favorable prognosis and survival in breast and pancreatic cancers.

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