Synonym: Acyl-Neuraminyl Hydrolase, Sialidase
|Related Categories||3.2.x.x Glycosidases, 3.x.x.x Hydrolases, Antibody Characterization and Analysis, Antibody Glycan Analysis, Application Index,|
|recombinant||expressed in E. coli|
|form||buffered aqueous solution|
|foreign activity||proteases, none detected|
Releases α(2→3)- and α(2→6)-linked N-acetylneuraminic acid from complex oligosaccharides.
Provided with 5× reaction buffer (250 mM sodium phosphate, pH 6.0).
Expressed in glycosidase-free hosts.
One unit will hydrolyze 1 μmole of 4-methylumbelliferyl α-
Solution in 20 mM Tris-HCl, pH 7.5, and 25 mM NaCl.
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buffered aqueous solution
Proteomics Grade, suitable for MALDI-TOF MS
recombinant, expressed in E. coli, buffered aqueous solution
Type V, lyophilized powder
Type VI, lyophilized powder, 6-10 units/mg protein (using NAN-lactose), 2-5 units/mg protein (mucin)
Certificate of Analysis
Certificate of Origin
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Keywords: Cell culture, Cell disruption, Cell signaling, Diagnostic, Digestions, Drug discovery, Functional genomics, Gene expression, Genomics, Metabolic Pathways, Molecular biology, Neuroscience, Proteomics
Neuraminidase inhibitors for influenza: a review and public health perspective in the aftermath of the 2009 pandemic. Beck CR, Sokal R, Arunachalam N, et al. Influenza Other Respi. Viruses 7 Suppl 1, 14-24, (2013)
In situ molecular identification of the influenza A (H1N1) 2009 Neuraminidase in patients with severe and fatal infections during a pandemic in Mexico City. Ocadiz-Delgado R, Albino-Sanchez ME, Garcia-Villa E, et al. BMC Infect. Dis. 13, 20, (2013)
Pathway Pattern-based prediction of active drug components and gene targets from H1N1 influenza's treatment with maxingshigan-yinqiaosan formula. Dai W, Chen J, Lu P, et al. Mol. Biosyst. 9(3), 375-85, (2013)
NA proteins of influenza A viruses H1N1/2009, H5N1, and H9N2 show differential effects on infection initiation, virus release, and cell-cell fusion. Chen Q, Huang S, Chen J, et al. PLoS ONE 8(1), e54334, (2013)
What is the role of respiratory viruses in community-acquired pneumonia?: What is the best therapy for influenza and other viral causes of community-acquired pneumonia? Pavia AT Infect. Dis. Clin. North Am. 27(1), 157-75, (2013)
Identification of critical residues in the hemagglutinin and neuraminidase of influenza virus H1N1pdm for vaccine virus replication in embryonated chicken eggs. Wang W, Lu J, Cotter CR, et al. J. Virol. 87(8), 4642-9, (2013)
Polar residues and their positional context dictate the transmembrane domain interactions of influenza A neuraminidases. Nordholm J, da Silva DV, Damjanovic J, et al. J. Biol. Chem. 288(15), 10652-60, (2013)
Degradation, foraging, and depletion of mucus sialoglycans by the vagina-adapted Actinobacterium Gardnerella vaginalis. Lewis WG, Robinson LS, Gilbert NM, et al. J. Biol. Chem. 288(17), 12067-79, (2013)
Identification of selective inhibitors for human neuraminidase isoenzymes using C4,C7-modified 2-deoxy-2,3-didehydro-N-acetylneuraminic acid (DANA) analogues. Zhang Y, Albohy A, Zou Y, et al. J. Med. Chem. 56(7), 2948-58, (2013)
Trypanosoma cruzi trans-sialidase initiates a program independent of the transcription factors RORγt and Ahr that leads to IL-17 production by activated B cells. Bermejo DA, Jackson SW, Gorosito-Serran M, et al. Nat. Immunol. 14(5), 514-22, (2013)
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