|Related Categories||Amino Acid Derivatives, Application Index, Arginine, Bioactive Small Molecules, Biochemicals and Reagents,|
|color||white to off-white|
|solubility||H2O: soluble50 mg/mL|
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An analog of arginine that inhibits NO production. It has multiple effects on the vascular system. Inhibits relaxation induced by acetylcholine and induces an increase in arterial blood pressure. Abolishes lecithinized superoxide dismutase induced vasodilation when used to pretreat aortic ring preparations of mice. Induces leukocyte adhesion and increases microvascular fluid and protein fluxes and permeability. It has also been used in many studies of learning and memory.
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Effects Of Tumor Necrosis Factor-alpha And Nitric Oxide On Prostaglandins Secretion By The Bovine Oviduct Differ In The Isthmus And Ampulla And Depend On The Phase Of The Estrous Cycle. Siemieniuch, M.J., et al. Exp. Biol. Med. 234, 1056-66, (2009)
Nitric oxide-angiotensin II interactions and renal hemodynamic function in patients with uncomplicated type 1 diabetes. Montanari A, Pelà G, Musiari L, et al. Am. J. Physiol. Renal Physiol. 305(1), F42-51, (2013)
Angiotensin II Type 1 receptor blockade protects endothelium-derived hyperpolarising factor-mediated relaxation in a rat model of monoarthritis. Mackenzie A, Dunning L, Ferrell WR, et al. Life Sci. 92(23), 1131-7, (2013)
Nitric oxide reduces Cl⁻ absorption in the mouse cortical collecting duct through an ENaC-dependent mechanism. Pech V, Thumova M, Dikalov SI, et al. Am. J. Physiol. Renal Physiol. 304(11), F1390-7, (2013)
Rats with adenine-induced chronic renal failure develop low-renin, salt-sensitive hypertension and increased aortic stiffness. Nguy L, Johansson ME, Grimberg E, et al. Am. J. Physiol. Regul. Integr. Comp. Physiol. 304(9), R744-52, (2013)
P2X7 receptor activation contributes to an initial upstream mechanism of lipopolysaccharide-induced vascular dysfunction. Chiao CW, da Silva-Santos JE, Giachini FR, et al. Clin. Sci. (Lond.) 125(3), 131-41, (2013)
Partial role of multiple pathways in infarct size limiting effect of quercetin and rutin against cerebral ischemia-reperfusion injury in rats. Annapurna A, Ansari MA, and Manjunath PM Eur. Rev. Med. Pharmacol. Sci. 17(4), 491-500, (2013)
The role of NO in the posterior hypothalamus in amygdala-generated pressor responses in conscious rats. Özyurt Bayraktar H, Yananlı H, Terzioğlu B, et al. Auton. Autacoid Pharmacol. 33(1-2), 7-16, (2013)
GABA-induced vasorelaxation mediated by nitric oxide and GABAA receptor in non diabetic and streptozotocin-induced diabetic rat vessels. Kamran M, Bahrami A, Soltani N, et al. Gen. Physiol. Biophys. 32(1), 101-6, (2013)
Modulation of stretch-induced myocyte remodeling and gene expression by nitric oxide: a novel role for lipoma preferred partner in myofibrillogenesis. Hooper CL, Paudyal A, Dash PR, et al. Am. J. Physiol. Heart Circ. Physiol. 304(10), H1302-13, (2013)
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