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N5751 Sigma

Nω-Nitro-L-arginine methyl ester hydrochloride

≥98% (TLC), powder

Synonym: L-NAME hydrochloride

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Description

Frequently Asked Questions

Frequently Asked Questions are available for this Product.

Packaging

1, 5, 10, 25 g in poly bottle

250 mg in poly bottle

Biochem/physiol Actions

An analog of arginine that inhibits NO production. It has multiple effects on the vascular system. Inhibits relaxation induced by acetylcholine and induces an increase in arterial blood pressure. Abolishes lecithinized superoxide dismutase induced vasodilation when used to pretreat aortic ring preparations of mice. Induces leukocyte adhesion and increases microvascular fluid and protein fluxes and permeability. It has also been used in many studies of learning and memory.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

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Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Frequently Asked Questions

Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis. These documents are located on the product detail page under Useful Links & Tools. Click on the following link to search for a Certificate of Analysis. Please click the following link to see the details on our Product Dating Information.
How do I get lot-specific information or a Certificate of Analysis?
A Certificate of Analysis is available by lot number and can be obtained through our Advanced Search Option: http://www.sigmaaldrich.com/catalog/AdvancedSearchPage.do
How do I find price and availability?
There are several ways to find pricing and availability for our products.  Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers. 
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS. To access the shipping information for this material, use the link on the product detail page for the product, or search here. 
What is the solution stability of Product N5751, L-NAME hydrochloride?
Although we do not perform solution stability studies, one literature reference recommends keeping solutions on ice during the course of one day.  This information is located on the product information sheet at this link:  http://www.sigmaaldrich.com/sigma/product%20information%20sheet/n5751pis.pdf
How do I sterilize a prepared solution of Product N5751, L-NAME hydrochloride?
Solutions of this product may be sterile-filtered.
My question is not addressed here, how can I contact Technical Service for assistance?
Use the option to the right to "Ask a Question" by email of a Technical Service Scientist.
Is Product N5751, L-NAME hydrochloride, an inhibitor of Nitric Oxide Synthase (NOS)?
L-NAME was described as a reversible, non-specific inhibitor of nitric oxide synthase by Khavandgar. S. et al., Pharmacol. Biochem. Behav., 74, 795 (2003).
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Protocols & Articles

Articles

Discover Bioactive Small Molecules for Nitric Oxide & Cell Stress Research

Exposure to harsh conditions, cellular damage, and other factors can cause stress on cells. Stress attributed directly and indirectly to oxygen is referred to as oxidative stress, which is imposed on...
Keywords: Antimicrobials, Bioactive small molecules, Cancer, Diseases, Neurodegenerative Diseases, Oxidations

Peer-Reviewed Papers
15

References

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