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  • N6163 - Anti-Nerve Growth Factor Receptor/TNFRSF16 antibody produced in goat

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N6163 Sigma

Anti-Nerve Growth Factor Receptor/TNFRSF16 antibody produced in goat

affinity isolated antibody, lyophilized powder

Synonym: Anti-LNGFR, Anti-Ngfr, Anti-Tnfrsf16, Anti-p75

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Description

Immunogen

purified, Sf21-derived recombinant human p75 neurotrophin R extracellular domain.

General description

Neurotrophins (NT) are growth factors that are essential for the development and maintenance of the nervous system. One of the receptors that mediate the effects of NTs is the Nerve Growth Factor Receptor/TNFRSF16 (p75NGFR, p75NTR). Nerve growth factor (NGF) binds to either to NGF receptor (NGFR) or the Trk receptor and can elicit biological responses through each of the receptors independently. NGFR mediates the effects of NGF that are important in the survival and differentiation of neurons and neural crest-derived cells during embryonic and early postnatal development and maintenance of peripheral neurons. Signaling of NGF through NGFR is also implicated in inflammation and allergic reactions. Expression of NGFR has been associated with favourable prognosis and survival in breast and pancreatic cancers
Anti-Nerve Growth Factor Receptor/TNFRSF16 recognizes human NGF R.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.

Application

Anti-Nerve Growth Factor Receptor/TNFRSF16 antibody may be used for immunoblotting at a working concentration of 0.1-0.2 μg/ml.

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Safety Information

Personal Protective Equipment  Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
RIDADR  NONH for all modes of transport
WGK Germany  1
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Monoclonal and polyclonal primary antibodies are focused on cell biology, neurobiology and molecular biology. Secondary antibodies targeting multiple host’s IgG are conjugated to alkaline phosphatase...
Keywords: Amplification, Buffers, Cell biology, Enzyme-linked immunosorbent assay, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Molecular biology, Phosphorylations, Purification, Western blot

Peer-Reviewed Papers
15

References

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