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N6414 Sigma

NN-DNJ

≥98% (HPLC)

DOWNLOAD MSDS (PDF)

  • CAS Number 81117-35-3

  • Empirical Formula (Hill Notation) C15H31NO4

  • Molecular Weight 289.41

  •  MDL number MFCD00905846

NN-DNJ ≥98% (HPLC)
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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Cell Stress, DNA Repair Proteins and Reagents, Nitric Oxide and Cell Stress More...
assay   ≥98% (HPLC)
form   solid
solubility   DMSO: >10 mg/mL
storage temp.   −20°C

Description

Biochem/physiol Actions

NN-DNJ is a glucosidase inhibitor that acts as a pharmacologic chaperone. NN-DNJ also acts synergistically with proteostasis modulators such as celastrol and MG132 to stabilize mutant proteins in properly folded states. NN-DNJ stabilizes various proteins against misfolding, increasing proper trafficking from the endoplasmic reticulum. There is potential use in studying diseases marked by misfolded proteins and has shown antiviral activity.

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