|Related Categories||Cell Biology, Cell Signaling and Neuroscience, Cell Stress, DNA Repair Proteins and Reagents, Nitric Oxide and Cell Stress More...|
|solubility||DMSO: >10 mg/mL|
NN-DNJ is a glucosidase inhibitor that acts as a pharmacologic chaperone. NN-DNJ also acts synergistically with proteostasis modulators such as celastrol and MG132 to stabilize mutant proteins in properly folded states. NN-DNJ stabilizes various proteins against misfolding, increasing proper trafficking from the endoplasmic reticulum. There is potential use in studying diseases marked by misfolded proteins and has shown antiviral activity.
Crystal structures of complexes of N-butyl-and N-nonyl-deoxynojirimycin bound to acid beta-glucosidase: insights into the mechanism of chemical chaperone action in Gaucher disease Brumshtein B, et al. J. Biochem. 282, 29052-29058, (2007)
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