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N6505 Sigma

β-Nicotinamide adenine dinucleotide 2′-phosphate reduced tetrasodium salt hydrate

≥95% (HPLC)

Synonym: β-NADPH, 2′-NADPH hydrate, Coenzyme II reduced tetrasodium salt, Dihydronicotinamide adenine dinucleotide phosphate tetrasodium salt, NADPH Na4, TPNH2 Na4, Triphosphopyridine nucleotide reduced tetrasodium salt

Properties

Related Categories Biochemicals and Reagents, Cofactors, Core Bioreagents, Enzymes, Inhibitors, and Substrates, Nucleosides and Nucleotides,
assay   ≥95% (HPLC)
  ≥95% (spectrophotometric assay)
storage temp.   −20°C

Description

Biochem/physiol Actions

Electron donor; cofactor for many redox enzymes including nitric oxide synthetase

Other Notes

Packaged based on solid weight.

Preparation Note

Enzymatically reduced.

Application

β-Nicotinamide adenine dinucleotide 2′-phosphate (NADP+) and β-Nicotinamide adenine dinucleotide 2′-phosphate, reduced (NADPH) comprise a coenzyme redox pair (NADP+:NADPH) involved in a wide range of enzyme catalyzed oxidation reduction reactions. The NADP+/NADPH redox pair facilitates electron transfer in anabolic reactions such as lipid and cholesterol biosynthesis and fatty acyl chain elongation. The NADP+/NADPH redox pair is used in a variety of antioxidation mechanism where it protects agains reactive oxidation species accumulation. NADPH is generated in vivio by the pentose phosphate pathway (PPP).

Price and Availability

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