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N7143 Sigma

Nigericin sodium salt

≥98% (TLC)

Synonym: Antibiotic K178, Antibiotic X464, Azalomycin M, Helexin C, Polyetherin A

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Description

Biochem/physiol Actions

Ionophore which disrupts membrane potential and stimulates ATPase activity in mitochondria.

Polyether ionophore which disrupts membrane potential and stimulates ATPase activity in mitochondria. Ion selectivity is K+> Rb+≥ Cs+>> Na+.

Other Notes

As ion-selective electrode - an efficient K+-carrier.1,2

Price and Availability


DISCOVER Bioactive Small Molecules

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Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 3462 6.1 / PGIII
WGK Germany 
3
RTECS 
QT6840000

Protocols & Articles

Peer-Reviewed Papers

References

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1. S. Cafferel-Mendez et al. Reprod. Nutr. Dev. 27, 921, (1989)

2. Ion-selective electrodes based on natural carboxylic polyether antibiotics. K. Suzuki et al. Anal. Chem. 60, 1714, (1988)

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Up-regulation of avian uncoupling protein in cold-acclimated and hyperthyroid ducklings prevents reactive oxygen species production by skeletal muscle mitochondria. Rey, B., et al. BMC Physiol. 10, 5, (2010)

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Monitoring Autophagy In Lysosomal Storage Disorders. Raben, N., et al. Meth. Enzymol. 453, 417-49, (2009)

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Changes In The Activity Of Defense Mechanisms Against Induced Acidosis During Meiotic Maturation In Mouse Oocytes. Erdogan, S., et al. Theriogenology 75, 1057-66, (2011)

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Phosphorylation-dependent stimulation of prostanoid synthesis by nigericin in cerebral endothelial cells. Parfenova, H., et al. Am. J. Physiol. 277, C728-C738, (1999)

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Phosphorylation-dependent stimulation of prostanoid synthesis by nigericin in cerebral endothelial cells. Parfenova, H., et al. Am. J. Physiol. 277, C728-C738, (1999)

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Effect of trace levels of nigericin on intracellular pH and acid-base transport in rat renal mesangial cells. Bevensee, M.O., et al. J. Membr. Biol. 169, 131-139, (1999)

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Effect of trace levels of nigericin on intracellular pH and acid-base transport in rat renal mesangial cells. Bevensee, M.O., et al. J. Membr. Biol. 169, 131-139, (1999)

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Activation of interleukin-1 β-converting enzyme by nigericin is independent of apoptosis. Watanabe, N., et al. Cytokine 10, 645-653, (1998)

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Activation of interleukin-1 β-converting enzyme by nigericin is independent of apoptosis. Watanabe, N., et al. Cytokine 10, 645-653, (1998)

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An improved flow cytometry assay to monitor phagosome acidification. Colas C, Menezes S, Gutiérrez-Martínez E, et al. J. Immunol. Methods 412, 1-13, (2014)

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Merck 14,6541

Beil. 19,V,12,550

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