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N7758 Sigma

Naloxone hydrochloride dihydrate

≥98% (TLC and titration), powder

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience,
InChI Key   TXMZWEASFRBVKY-IOQDSZRYSA-N
assay   ≥98% (TLC and titration)
form   powder
optical activity   [α]25/D −178.6°, c = 2.5 in H2O(lit.)
color   white
solubility   ethanol: soluble3.3 mg/mL (stable for several months refrigerated if protected from light.)
  H2O: soluble50 mg/mL (stable for several months refrigerated if protected from light.)
storage temp.   2-8°C
Gene Information   human ... OPRD1(4985), OPRK1(4986), OPRM1(4988), OPRS1(10280)

Description

Biochem/physiol Actions

Competitive antagonist for μ, κ, δ, and σ opioid receptors; blocks the action of σ-agonists at opioid sites.

Caution

Light sensitive.

Packaging

1, 5 g in poly bottle

250 mg in poly bottle

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

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Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles
Peer-Reviewed Papers
15

References

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