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N7912 Sigma

NESS 0327

≥98% (HPLC)

Synonym: N-Piperidinyl-[8-chloro-1-(2,4-dichlorophenyl)-1,4,5,6-tetrahydrobenzo-[6,7]cycloheptal[1,2-c]pyrazole-3-carboxamide

  • CAS Number 494844-07-4

  • Empirical Formula (Hill Notation) C24H23Cl3N4O

  • Molecular Weight 489.82

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Properties

Related Categories Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Cannabinoids, Cell Biology, Cell Signaling and Neuroscience,
assay   ≥98% (HPLC)
color   white
solubility   DMSO: ~4 mg/mL
  H2O: insoluble
storage temp.   2-8°C

Description

Biochem/physiol Actions

Potent cannabinoid CB1 receptor antagonist (Ki= 350 fM) with more than 60,000-fold selectivity for the CB1 receptor. Antagonizes the nociceptive effects produced by WIN 55,212-2 in both tail-flick and hot-plate tests. Useful as a tool to study the involvement of CB1 receptor in psychosis, food intake and cognitive impairment.

Features and Benefits

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Price and Availability


DISCOVER Bioactive Small Molecules

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Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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