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N8028 Sigma

Nikkomycin Z from Streptomyces tendae

≥90% (HPLC)

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Properties

Related Categories Antibiotics, Antibiotics A to Z, Antibiotics N-S, Antifungal, Biochemicals and Reagents,
InChI Key   WWJFFVUVFNBJTN-JKEIIPFCSA-N
assay   ≥90% (HPLC)
composition   Carbon, 47.68-49.28%
  Nitrogen, 13.34-14.94%
solubility   H2O: soluble5 mg/mL
Mode of action   cell wall synthesis | interferes
  enzyme | inhibits
antibiotic activity spectrum   fungi
storage temp.   2-8°C

Description

Packaging

5 mg in glass bottle

Application

Nikkomycin Z is used as a selective competitive inhibitor of chitin synthetase 3 in studies on fungal cell wall development. It is a potential treatment for human Encephalitozoon hellem, a microsporidian species and is used to study the changes of chitin and β--glucan under Nikkomycin Z exposure.

Biochem/physiol Actions

Nikkomycin Z inhibits chitin synthase from converting UDP-GlcNAc into cell wall chitin due to its structural resemblance to UDP-N-acetylglucosamine. Nikkomycin Z has potent antifungal, insecticidal and acaridicial activity.

Price and Availability


Amplified Detection
Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
BA2928200
Protocols & Articles
Peer-Reviewed Papers
15

References

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