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N8768 Sigma

Natriuretic Peptide, C-Type

≥95% (HPLC)

Synonym: CNP

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Natriuretic Peptides, Neuropeptides, Peptides and Proteins,
InChI Key   UHSBKBYWHCBDCJ-DYGWFTAGSA-N
assay   ≥95% (HPLC)
composition   Peptide content, ≥65%
storage temp.   −20°C
Gene Information   human ... NPPC(4880)

Description

Amino Acid Sequence

Gly-Leu-Ser-Lys-Gly-Cys-Phe-Gly-Leu-Lys-Leu-Asp-Arg-Ile-Gly-Ser-Met-Ser-Gly-Leu-Gly-Cys [Disulfide Bridge: 6-22]

Biochem/physiol Actions

C-type natriuretic peptide is produced in the hypothalamus, anterior pituitary, and most major endocrine glands. It has potent venodilatory and coronary vasodilatory effects, but minimal effects on renal function.

Natriuretic Peptide, C-Type (NPC) plays a vital role in regulation of blood pressure and body fluid homeostasis. NPC-mediated signaling is essential for endochondral ossification. NPC acts as a ligand for natriuretic peptide receptor B (NPR-B). NPC interacts with receptors on vascular smooth muscle cells (VSMCs) and functions as an autocrine/paracrine endothelium-derived hormone. It is also implicated in the endothelial dysfunction and regulation of adipogenesis, which has a crucial role in the development of obesity in childhood. NPC has potential as a marker for obesity and bone injury induced by steroid hormones. In vitro studies show that NPC is involved in the inhibition of smooth muscle cell proliferation, natriuresis, diuresis, vasodilation and inhibition of the renin- angiotensin system. NPC is associated with the development of myocardial infarction and heart failure. Plasma NPC levels can be used as a biomarker for the therapeutic efficacy of metoprolol on postural tachycardia syndrome (POTS) in children.

General description

Natriuretic Peptide, C-Type (NPPC/ CNP) is a 22 amino acid peptide encoded by NPPC gene mapped to human chromosome 2q37.1. It belongs to the natriuretic peptide family.

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Amplified Detection

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Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Articles

GC Analysis of 'Positive List' Chemicals (Mix 5) on SLB®-5ms

From our library of Articles, Sigma-Aldrich presents GC Analysis of 'Positive List' Chemicals (Mix 5) on SLB®-5ms
Keywords: Chromatography, Gas chromatography, Herbicides, Pesticides, Purification

Peer-Reviewed Papers
15

References

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